Target detection in healthy 4-week old piglets from a passive two-tone auditory oddball paradigm

• Authors: Rachanna Oeur, Emory University; Susan Margulies, Emory University
• Journal Title: BMC NEUROSCIENCE
• Volume: Volume 21, Number 1
• Publisher: BMC | 2020-12-07, Pages 52-52
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1186/s12868-020-00601-4
• Subjects: Biology, Neuroscience; Engineering, Biomedical
• Keywords: Science & Technology; Life Sciences & Biomedicine; Neurosciences; Neurosciences & Neurology; Auditory oddball paradigm; EEG; Event-related potential; Porcine; TRAUMATIC BRAIN-INJURY; ANIMAL-MODELS; MISMATCH NEGATIVITY; CHILDREN; POTENTIALS; NEUROPATHOLOGY; SCHIZOPHRENIA; IMPAIRMENT; CONCUSSION; DISABILITY

Abstract

Background: Passive auditory oddball tests are effort independent assessments that evaluate auditory processing and are suitable for paediatric patient groups. Our goal was to develop a two-tone auditory oddball test protocol and use this clinical assessment in an immature large animal model. Event-related potentials captured middle latency P1, N1, and P2 responses in 4-week old (N = 16, female) piglets using a custom piglet 32- electrode array on 3 non-consecutive days. The effect of target tone frequency (250 Hz and 4000 Hz) on middle latency responses were tested in a subset of animals. Results: Results show that infrequent target tone pulses elicit greater N1 amplitudes than frequent standard tone pulses. There was no effect of day. Electrodes covering the front of the head tend to elicit greater waveform responses. P2 amplitudes increased for higher frequency target tones (4000 Hz) than the regular 1000 Hz target tones (p < 0.05). Conclusions: Two-tone auditory oddball tests produced consistent responses day-to-day. This clinical assessment was successful in the immature large animal model.