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A.K.E. and D.J.K. designed research; A.K.E., A.C.W., R.A.M., S.M.K., Y.B., and D.J.K. performed research; A.K.E., A.C.W., R.A.M., D.A.M., S.M.K., Y.B., M.J.R., and D.J.K. analyzed data; and A.K.E. and D.J.K. wrote the paper.
We thank M. Rosenfeld (University of California San Diego) for providing Lsd1 deletion mice and D. Castrillon for providing the Vasa-Cre mice.
The authors declare no competing interest.
We thank N. Seyfried, R. Betarbet, and Mr. Gearing, from the Emory University Alzheimer’s Disease Research Center (P50 AG025688), National Institute of Neurological Disorders and Stroke (NINDS), Emory University Neuroscience Core Facilities (P30NS055077) for tissue processing and providing PHF1 antibody; J. Alcudia of the Stanford University Gene Vector and Virus Core for help with virus generation and production; the Georgia Genomics and Bioinformatics Core, which provided the RNA library preparation and sequencing service; J. Schroeder from the Emory University Rodent Behavioral Core for help with rotatord and grid performance assays, supported by the Emory University Neuroscience NINDS Core Facilities (P30NS055077) with further support provided by the Georgia Clinical and Translational Science Alliance of the NIH under Award UL1TR002378; and J. Park from the Emory University Center for Systems Imagining for performing MRI supported by the National Center for Advancing Translational Sciences of the NIH under Award UL1TR000454. We would also like to thank M. J. Rowley and V. Corces for assistance in RNA sequencing analysis; K. Porter-Stransky and D. Weinshenker for providing PS19 Tau mice and for teaching the stereotaxic surgery procedure; L. R. Lym and Dr. Lerit for assistance with confocal imagining; and D. Weinshenker, A. Levey, C. Bean, and T. Caspary for comments on the manuscript and assistance throughout. Additionally we would like to thank fellow D.J.K. laboratory members for assistance experimentally and intellectually. A.K.E. was supported by the National Institute of General Medicine training grant (T32 GM008367-26) and a National Research Service Award Fellowship from NINDS (F31 NS098663-02). D.A.M. was supported by a research supplement to promote diversity in health-related research from NINDS (1R01NS087142). S.M.K. was supported by NINDS Training in Translational Research in Neurology grant (5T32 NS007480-17). M.J.R. is supported by the NIH Pathway to Independence Award K99/R00 GM127671. The work was supported by a grant to D.J.K. from NINDS (1R01NS087142).
© 2020 The Author(s)