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Author Notes:

mahmou22@msu.edu

The authors declare no competing financial interest.

Subjects:

Research Funding:

M.M. acknowledges support by IGNITE Award from the Connors Center for Women’s Health & Gender Biology and Precision Health Medicine at Michigan State University.

Keywords:

  • Science & Technology
  • Physical Sciences
  • Chemistry, Multidisciplinary
  • Chemistry
  • ISCHEMIA-REPERFUSION INJURY
  • SENSITIVITY CARDIAC TROPONIN
  • PERMEABILITY TRANSITION PORE
  • CREATINE-KINASE MB
  • TUMOR-ASSOCIATED MACROPHAGES
  • STIMULI-RESPONSIVE POLYMERS
  • PROTEIN CORONA COMPOSITION
  • WALLED CARBON NANOTUBES
  • 2013 ACCF/AHA GUIDELINE
  • ASSOCIATION TASK-FORCE

Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities

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Journal Title:

CHEMICAL REVIEWS

Volume:

Volume 119, Number 21

Publisher:

, Pages 11352-11390

Type of Work:

Article | Post-print: After Peer Review

Abstract:

The adult myocardium has a limited regenerative capacity following heart injury, and the lost cells are primarily replaced by fibrotic scar tissue. Suboptimal efficiency of current clinical therapies to resurrect the infarcted heart results in injured heart enlargement and remodeling to maintain its physiological functions. These remodeling processes ultimately leads to ischemic cardiomyopathy and heart failure (HF). Recent therapeutic approaches (e.g., regenerative and nanomedicine) have shown promise to prevent HF postmyocardial infarction in animal models. However, these preclinical, clinical, and technological advancements have yet to yield substantial enhancements in the survival rate and quality of life of patients with severe ischemic injuries. This could be attributed largely to the considerable gap in knowledge between clinicians and nanobioengineers. Development of highly effective cardiac regenerative therapies requires connecting and coordinating multiple fields, including cardiology, cellular and molecular biology, biochemistry and chemistry, and mechanical and materials sciences, among others. This review is particularly intended to bridge the knowledge gap between cardiologists and regenerative nanomedicine experts. Establishing this multidisciplinary knowledge base may help pave the way for developing novel, safer, and more effective approaches that will enable the medical community to reduce morbidity and mortality in HF patients.
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