Ceruloplasmin and Coronary Heart Disease-A Systematic Review

• Authors: Antonio P. Arenas de Larriva, University of Cordoba; Laura Limia-Perez, University of Cordoba; Juan F. Alcala-Diaz, University of Cordoba; Alvaro Alonso, Emory University; Jose Lopez-Miranda, University of Cordoba; Javier Delgado-Lista, University of Cordoba
• Journal Title: NUTRIENTS
• Volume: Volume 12, Number 10
• Publisher: MDPI | 2020-10-01, Pages 1-15
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.3390/nu12103219
• Subjects: Health Sciences, Nutrition; Health Sciences, Medicine and Surgery
• Keywords: Science & Technology; Life Sciences & Biomedicine; Nutrition & Dietetics; ceruloplasmin; coronary heart disease; inflammation; SENSITIVE PLASMA-PROTEINS; DENSITY-LIPOPROTEIN OXIDATION; MYOCARDIAL-INFARCTION; SERUM CERULOPLASMIN; CARDIOVASCULAR RISK; NITRIC-OXIDE; UPDATE; COPPER; LEVEL; ASSOCIATION

Abstract

Several studies indicate that oxidative stress might play a central role in the initiation and maintenance of cardiovascular diseases. It remains unclear whether ceruloplasmin acts as a passive marker of inflammation or as a causal mediator. To better understand the impact of ceruloplasmin blood levels on the risk of cardiovascular disease, and paying special attention to coronary heart disease, we conducted a search on the two most commonly used electronic databases (Medline via PubMed and EMBASE) to analyze current assessment using observational studies in the general adult population. Each study was quality rated using criteria developed by the US Preventive Services Task Force. Most of 18 eligible studies reviewed support a direct relationship between ceruloplasmin elevated levels and incidence of coronary heart disease. Our results highlight the importance of promoting clinical trials that determine the functions of ceruloplasmin as a mediator in the development of coronary heart disease and evaluate whether the treatment of elevated ceruloplasmin levels has a role in the prognosis or prevention of this condition.