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kye@emory.edu; zhzhqing1990@163.com
K.Y. conceived the project, designed the experiments, analyzed the data, and wrote the manuscript. G.C., Z.W., and E.H.A. designed and performed most of the experiments and analyzed the data. S.S.K. conducted stereotaxic injection of the viral vectors. Y.X. prepared iPSC-derived neurons. X.L. prepared primary neurons and assisted with in vivo and in vitro experiments. I.M.S. and F.P.M. provided the AAV-AEP C189S viral vectors. Z.Z. assisted with data analysis and interpretation and critically read the manuscript.
The authors declare that they have no competing interests.
This work is supported by a grant from the National Institutes of Health (RF1, AG051538) to K.Y. and the State Key Program of the National Natural Science Foundation of China (no. 81671051) to Z.Z. This study was supported in part by the Rodent Behavioral Core (RBC), which is subsidized by the Emory University School of Medicine and is one of the Emory Integrated Core Facilities. We thank ADRC at Emory University for human patients with AD and HC samples (P30 AG066511). Additional support was provided by the Viral Vector Core of the Emory Neuroscience NINDS Core Facilities (P30NS055077). Further support was provided by the Georgia Clinical and Translational Science Alliance of the National Institutes of Health under Award Number UL1TR002378.
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