Spatial and temporal patterns of Ross River virus in south east Queensland, Australia: Identification of hot spots at the rural-urban interface

• Authors: Amanda K. Murphy, QIMR Berghofer Medical Research Institute; Julie Clennon, Emory University; Gonzalo Vazquez-Prokopec, Emory University; Cassie C. Jansen, Queensland Health; Francesca D. Frentiu, Queensland University of Technology; Louise M. Hafner, Queensland University of Technology; Wenbiao Hu, Queensland University of Technology; Gregor J. Devine, QIMR Berghofer Medical Research Institute
• Journal Title: BMC Infectious Diseases
• Volume: Volume 20, Number 1
• Publisher: BMC | 2020-10-02, Pages 722-722
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1186/s12879-020-05411-x
• Subjects: Biology, Virology; Health Sciences, Public Health
• Keywords: Arbovirus; Epidemic; Queensland; Ross River virus; Spatial; Urban; Adult; Alphavirus Infections; Female; Humans; Incidence; Male; Middle Aged; Queensland; Ross River virus; Rural Health; Urban Health

Abstract

Background: Ross River virus (RRV) is responsible for the most common vector-borne disease of humans reported in Australia. The virus circulates in enzootic cycles between multiple species of mosquitoes, wildlife reservoir hosts and humans. Public health concern about RRV is increasing due to rising incidence rates in Australian urban centres, along with increased circulation in Pacific Island countries. Australia experienced its largest recorded outbreak of 9544 cases in 2015, with the majority reported from south east Queensland (SEQ). This study examined potential links between disease patterns and transmission pathways of RRV. Methods: The spatial and temporal distribution of notified RRV cases, and associated epidemiological features in SEQ, were analysed for the period 2001-2016. This included fine-scale analysis of disease patterns across the suburbs of the capital city of Brisbane, and those of 8 adjacent Local Government Areas, and host spot analyses to identify locations with significantly high incidence. Results: The mean annual incidence rate for the region was 41/100,000 with a consistent seasonal peak in cases between February and May. The highest RRV incidence was in adults aged from 30 to 64 years (mean incidence rate: 59/100,000), and females had higher incidence rates than males (mean incidence rates: 44/100,000 and 34/100,000, respectively). Spatial patterns of disease were heterogeneous between years, and there was a wide distribution of disease across both urban and rural areas of SEQ. Overall, the highest incidence rates were reported from predominantly rural suburbs to the north of Brisbane City, with significant hot spots located in peri-urban suburbs where residential, agricultural and conserved natural land use types intersect. Conclusions: Although RRV is endemic across all of SEQ, transmission is most concentrated in areas where urban and peri-urban environments intersect. The drivers of RRV transmission across rural-urban landscapes should be prioritised for further investigation, including identification of specific vectors and hosts that mediate human spillover.