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Author Notes:

Correspondence: Kenneth J. Goodrum, Department of Zoological and Biomedical Sciences, and College of Osteopathic Medicine, Ohio University, Athens, OH 45701

Subjects:

Research Funding:

None declared

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Cell Biology
  • Hematology
  • Immunology

PERITONEAL-MACROPHAGES OF PATHOGEN-FREE RATS BUT NOT OF CONVENTIONAL RATS SECRETE ELASTOLYTIC ACTIVITY

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Journal Title:

Journal of Leukocyte Biology

Volume:

Volume 36, Number 2

Publisher:

, Pages 161-171

Type of Work:

Article | Final Publisher PDF

Abstract:

Elicited peritoneal macrophages from Sprague-Dawley rats conventionally bred and housed failed, as we have reported, to produce detectable elastolytic activity in culture. They did produce lysozyme and plasminogen activator. We now show that in contrast to these cells, macrophages from pathogen-free, barrier-sustained rats produced readily demonstrable elastolytic activity. Rats raised pathogen-free and subsequently housed conventionally for 2-4 wk appeared to lose the capacity to afford macrophages producing elastase. At the same time they acquired infections with several rat pathogens including Spironucleus muris, Kilham rat virus, sialodacryoadinitis virus, and mycoplasma pulmonis. The acquisition by the rats of one or more of these infections, conditions conducive to infection, or both factors may have suppressed their capacity to yield elastolytic activity.

Copyright information:

© 1984 by the Society for Leukocyte Biology

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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