Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia

• Authors: Sarah H. Alfaraj, The University of British Columbia; Jaffar A. Al-Tawfiq, Indiana University School of Medicine; Talal A. Altuwaijri, King Saud University; Ziad Memish, Emory University
• Journal Title: Frontiers of Medicine
• Volume: Volume 13, Number 1
• Publisher: Springer Nature | 2019-02-01, Pages 126-130
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1007/s11684-017-0603-y
• Subjects: Health Sciences, Epidemiology; Health Sciences, Public Health; Biology, Virology; Health Sciences, Radiology
• Keywords: MERS-CoV; Middle East respiratory syndrome coronavirus; pediatrics; pregnancy; Adolescent; Child; Coronavirus Infections; Diarrhea; Dyspnea; Female; Fever; Humans; Infant; Lung; Male; Middle East Respiratory Syndrome Coronavirus; Pleural Effusion; Radiography, Thoracic; Saudi Arabia

Abstract

Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%–60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April 19, 2016 reported 31 pediatric MERS-CoV cases. In this paper, we present the clinical and laboratory features of seven patients with pediatric MERS. Five patients had no underlying medical illnesses, and three patients were asymptomatic. Of the seven cases, four (57%) patients sought medical advice within 1–7 days from the onset of symptoms. The three other patients (43%) were asymptomatic and were in contact with patients with confirmed diagnosis of MERS-CoV. The most common presenting symptoms were fever (57%), cough (14%), shortness of breath (14%), vomiting (28%), and diarrhea (28%). Two (28.6%) patients had platelet counts of < 150 × 10 9 /L, and one patient had an underlying end-stage renal disease. The remaining patients presented with normal blood count, liver function, and urea and creatinine levels. The documented MERS-CoV Ct values were 32–38 for four of the seven cases. Two patients (28.6%) had abnormal chest radiographic findings of bilateral infiltration. One patient (14.3%) required ventilator support, and two patients (28.6%) required oxygen supplementation. All the seven patients were discharged without complications.