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Author Notes:

Correspondence: Varun K. Phadke, MD, Division of Infectious Diseases, Health Sciences Research Building, Room W-328, 1760 Haygood Drive NE, Atlanta, GA 30322 (vphadke@emory.edu).

The authors would like to thank The Francis I. Proctor Foundation, the UCSF Department of Ophthalmology at the University of California, San Francisco, in San Francisco, California, and Dr. Thuy Doan (UCSF Department of Ophthalmology).

Disclosures: Dr. Shantha’s work is supported by the National Eye Institute of the National Institutes of Health (K23EY030159). Dr. O’Keefe has served on the advisory board of Eyepoint Pharmaceuticals. Both authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.

Subjects:

Research Funding:

Dr. Shantha’s work is supported by the National Eye Institute of the National Institutes of Health (K23EY030159).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • Microbiology
  • HIV
  • HTLV-1
  • uveitis
  • metagenomic deep sequencing

Relapsing Uveitis due to Human T-lymphotropic Virus Type 1 in a Patient Living With HIV Diagnosed by Metagenomic Deep Sequencing

Tools:

Journal Title:

Open Forum Infectious Diseases

Volume:

Volume 7, Number 3

Publisher:

, Pages 1-3

Type of Work:

Article | Final Publisher PDF

Abstract:

HIV infection can result in vision loss from different causes, including HIV retinopathy and uveitis secondary to other infections, such as toxoplasmosis and viral retinitis. It is imperative to identify any infectious causes of uveitis to successfully treat the condition and prevent further vision loss. Metagenomic deep sequencing (MDS) is an emerging technology that presents an unbiased approach to the evaluation of clinical syndromes, including uveitis, that have not been diagnosed by pathogen-specific testing. Herein we present a case of a woman living with HIV with 11 years of relapsing bilateral uveitis refractory to systemic corticosteroid therapy who was diagnosed with human T-lymphotropic virus type 1 (HTLV-1)–associated uveitis by this technology. We also briefly review the literature of MDS as a diagnostic tool and the epidemiology, pathogenesis, and diagnosis of HTLV-1-associated uveitis.

Copyright information:

© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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