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Author Notes:

Correspondence: Xiaoping P. Hu, Ph.D., Provost Fellow, Professor and Chair Department of Bioengineering, University of California, Riverside, Materials Science and Engineering 205, Phone: (951) 827-2925, Fax: (951) 827-6416, xhu@engr.ucr.edu

J.L.: Research Project: conception, organization, execution. Statistical analysis: Design, execution. Manuscript: Writing of the first draft, review and critique.

N.H.: Research Project: conception, organization, execution. Statistical analysis: Design, execution. Manuscript: Writing of the first draft, review and critique.

D.H.: Research Project: conception, organization, execution. Statistical analysis: Execution, review and cirituqe. Manuscript: Writing of the first draft, review and critique.

S.C.: Research project: execution. Statistical analysis: Review and critique. Manuscript: Review and critique.

F.Y.: Research project: execution. Statistical analysis: Review and critique. Manuscript: Review and critique.

S.F.: Research Project: conception, execution. Statistical analysis: Review and critique. Manuscript: Review and critique.

X.H.: Research Project: conception, execution. Statistical analysis: Review and critique. Manuscript: Review and critique.

Disclosures: nothing additional to report.

Subjects:

Research Funding:

Xiaoping Hu, Jason Langley, and Daniel Huddleston receive funding from the Michael J. Fox Foundation (MJF 10854). Recruitment of control individuals for this research was facilitated by the Emory Alzheimer’s Disease Research Center (NIH-NINDS P50-AG025688).

The Emory MRI facility used in this study is supported in part by funding from a Shared Instrumentation Grant (S10) grant 1S10OD016413–01 to the Emory University Center for Systems Imaging Core.

Fuhua Yan and Naying He receive funding from the Science and Technology Commission of Shanghai Municipality (17411952700).

Naying He receives funding from the Shanghai Sailing Program (18YF1414700).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Clinical Neurology
  • Neurosciences & Neurology
  • iron
  • MRI
  • neuromelanin
  • Parkinson's disease
  • substantia nigra pars compacta
  • Substantia nigra
  • Brain
  • Diagnosis
  • Degeneration
  • Pathology
  • T1

Reproducible detection of nigral iron deposition in 2 Parkinson's disease cohorts

Tools:

Journal Title:

Movement Disorders

Volume:

Volume 34, Number 3

Publisher:

, Pages 416-420

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Background: Previous studies investigating nigral iron accumulation used T 2 or T 2 *-weighted contrasts to define the regions of interest (ROIs) in the substantia nigra with mixed results. Because these contrasts are not sensitive to neuromelanin, ROIs may have inadvertently missed the SNpc. An approach sensitive to neuromelanin should yield consistent results. We examine iron deposition in ROIs derived from neuromelanin-sensitive and T 2 *-weighted contrasts, respectively. Methods: T 1 -weighted and multiecho gradient echo imaging data were obtained in 2 cohorts. Multiecho gradient echo imaging data were analyzed using neuromelanin-sensitive SNpc ROIs as well as T 2 *-weighted SNr ROIs. Results: When compared with controls, significantly larger R 2 * values were seen in the SNpc of PD patients in both cohorts. Mean R 2 * values in the SNr of PD patients showed no consistency, with 1 cohort showing a small, statistically significant increase, whereas the other cohort exhibited no statistical difference. Conclusion: Mean R 2 * in the SNpc defined by neuromelanin-sensitive MRI is significantly increased in PD.

Copyright information:

© 2018 International Parkinson and Movement Disorder Society.

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