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Author Notes:

Correspondence: Dr. Patel, Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, 2015 Uppergate Dr. NE, 3rd floor, Atlanta, GA 30322. Tel 404-727-3236. rmpatel@emory.edu

Disclosures: Dr. Josephson has received oxygenation monitoring equipment (e.g. NIRS and pulse oximetry) from Medtronic, Inc. The company had no role in this review. The other authors have no conflicts of interest to report.


Research Funding:

The review was supported, in part, by the National Institutes of Health under award K23 HL128942 (R.M.P.), which had no role in the content of this review.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Obstetrics & Gynecology
  • Pediatrics
  • Infant
  • Neonate
  • Preterm
  • Blood
  • Oxygenation
  • Morbidity
  • Near-infrared spectroscopy
  • Splanchnic tissue oxygenation
  • Birth weight infants
  • Preterm infant
  • Iron supplementation
  • Nitric oxide
  • Erythropoietin
  • Increase
  • Risk
  • Association

Epidemiology of Necrotizing Enterocolitis New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia


Journal Title:

Clinics in Perinatology


Volume 46, Number 1


, Pages 101-+

Type of Work:

Article | Post-print: After Peer Review


This article summarizes available evidence on the relationship between red blood cell transfusion and anemia, and necrotizing enterocolitis (NEC). We review recent studies that highlight the uncertainty of the effect of red blood cell transfusion on NEC and the potential role of anemia. We also discuss potential pathophysiologic effects of both red blood cell transfusion and anemia and highlight strategies to prevent anemia and red blood cell transfusion. We also discuss ongoing randomized trials that are likely to provide important new evidence to guide red blood cell transfusion practices.

Copyright information:

© 2018 Elsevier Inc. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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