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S.A.B. developed the methodology, carried out the data analysis and was lead author of the manuscript. A.B.H., M.T.S., K.L. and E.C. extracted and analyzed mRNA, performed RNA-seq and interpreted sequencing data. T.C.C. and J.R. identified patient samples to be included in the Marshfield cohort, and confirmed diagnosis by pathology review. Y.G.P. and S.S.B. performed pathological analysis, and extracted mRNA. S.A.B., A.B.H., Y.G.P. and S.S.B. designed the project. All authors reviewed the manuscript.
We are grateful to staff at Marshfield Clinic’s Center for Clinical Epidemiology and Population Health, Histology Department, and Office of Research Computing and Analytics for assistance in obtaining clinical data and glass slides of tumor samples for the Marshfield cohort. We thank Brent Harker, Notre Dame Genomics & Bioinformatics Core Facility, for organizing, executing and establishing protocols for RNA-seq analysis of the Marshfield cohort samples.
The University of Notre Dame has filed a patent application for ColoType with SAB as inventor. SAB is a founder of Claris GenomiX, Inc which is has obtained a license for this technology. Other authors reported no competing interests.
Research partially supported by a Grant from Indiana Clinical Translational Sciences Institute (Grant no. PDT 468).
© The Author(s) 2020