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Keywords:

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • COVID-19
  • COVID-19 Testing
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Reproducibility of Results
  • SARS-CoV-2
  • Sensitivity and Specificity
  • Specimen Handling
  • Turbinates

Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2

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Journal Title:

Scientific Reports

Volume:

Volume 11, Number 1

Publisher:

, Pages 14903-14903

Type of Work:

Article

Abstract:

The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88–1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.
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