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Author Notes:

Correspondence: Christopher Haiman at Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504, Los Angeles, CA 90033, USA. Tel: +1 3234427755, Fax: +1 3234427749, haiman@usc.edu

or ari North at Department of Epidemiology, UNC Gillings School of Global Public Health, and Carolina Center for Genome Sciences, 137 E Franklin St., Suite 306, Chapel Hill, NC 27514, USA. Tel: +1 9199662148, Fax: +1 9199669800, kari_north@unc.edu

Design and/or Management of the Individual Studies: AA, AAA, CBA, CIA, DKA, LA, MCA, MAA, SA, CHB, DMB, DWB, EPB, EVB, GB, IBB, JPB, NPB, LB, SIB, WJB, CC, GC, GSC, JC, LC, MC, NEC, QC, RSC, SJC, JD, PD, RWD, SLD, JD, MKE, TLE, CF, JKF, EMG, PJG, SFAG, AH, AJMH, BEH, BVH, CAH, CCH, DH, HH, KJH, JJH, JNH, UJH, SAI, EMJ, FJ, JMJ, CK, DLK, EAK, EKK, LNK, LK, RAK, SJK, SK, LL, AML RL, SL, YL, ABM, BM, KRM, RCM, THM, JHM, IHM, IM, KEN, MCYN, SN, CND, UN, BN, SN, KLN, TOO, OO, OIO, BP, UP, BMP, CAP, GP, JRP, MFP, PAP, SRP, EAR, BAR, CNR, SR, JLR-G, ABS, AGS, JLS, LBS, PJS, VJH, SBS, SS, MS, IJS, SSS, HT, MJT, MAT, MV, JSWXW, JKW, SMW, LKW, MW, JJY, NAZ, RGZ, WZ, ABZ, KAZ, YZ, XZ

Genotyping: AB, UB, SJC, YIC, DD, SFAG, XG, DGH, JHH, JNH, TDH, TH, KCJ, YL, YCL, WM, RN, JRP, NDP, SS, DJV

Phenotyping: AAA, DKA, MAA, EPB, RSC, ED, BIF, OG, SFAG, JH, TH, KCJ, AK, CK, EKK, SL, JEM, MN, RN, AO, HO-B, BMP, JRP, SRP, CNR, ER, SR, BS, DS, LS, BOT, TRY

Statistical Methods and Data analysis: AAA, DKA, LFB, CWKC, GKC, GC, NEC, WC, GAC, YIC, JD, PD, TLE, CF, MFF, JPB, EMG, MG, OG, XG, CAH, MRI, AK, BJK, CK, EKK, SJK, CDL, GL, G Li, HL, KL, LAL, RJFL, VL, YL, Youfang Liu, YCL, KL, BM, KLM, YAM, AN, KEN, MAN, MCYN, AND, CDP, JRP, EAR, SKR, BP, APR, LJR-T, DAS, EKS, E Schadt, YVS, BOT, KCT, DRV-E, MKW, ZW, LKW, TWW, LRY, JZ, JHZ, NAZ, JZ, JMZ, WZ

Writing Group: GKC, TLE, MG, BEH, JNH, RJFL, CAH, LAL, KLM, KEN, MCYN, CP, GP, APR, KCT

Critical Review of Manuscript: AAA, AA, CBA, CIA, DKA, LA, MAA, MCA, SA, AB, CHB, DMB, DWB, EPB, EVB, GB, IBB, JPB, LFB, LB, SIB, UB, WJB, CWKC, CC, FC, GAC, GKC, GC, G Chen, JC, LC, MC, NEC, QC, RSC, SJC, W-MC, Y-DIC, DD, ED, JD, PD, RWD, SLD-H, MKE, TLE, CF, JKF, MFF, BIF, EMG, GSG, MG, OG, PJG, SFAG, WTG, XG, AJMH, AH, BEH, BVH, CAH, CCH, DGH, DH, HH, JJH, JNH, KJH, TDH, TH, T Harris, VJH, JHM, MRI, SAI, EMJ, JMJ, KCJ, AK, BJK, CK, DLK, EAK, EKK, LNK, LK, RAK, SJK, SLRK, SK, AML, CDL, GL, G Li, HL, KL, LAL, LL, MCL, RJFL, SL, VL, YL, Youfang Liu, YCL, ABM, BM, JCM, JEM, LHM, KLM, KRM, RCM, THM, WM, YAM, IM-B, AN, BN, KEN, KLN, MAN, MCYN, MN, RN, SN, UN, CN-D, OIO, OO, TOO, AO, HO-B, BMP, BP, CAP, CDP, GP, JRP, MFP, NDP, PAP, SRP, UP, APR, BAR, CNR, ER, SKR, SR, JLR-G, EAR-N, LJR-T, ABS, AGS, BS, DAS, DS, EKS, E Schadt, IJS, JLS, LBS, LS, MMS, MRS, PJS, SBS, SSS, YVS, BOT, KCT, MAT, HT, MJT, MV, DJV, DRVE, JKW, KW, MW, SMW, S-YW, SW-S, TWW, XW, ZW, LKW, JSW, MKW, JJY, LRY, TRY, ABZ, JZ, JMZ, JHZ, KAZ, NAZ, RGZ, WZ, W Zheng, XZ, YZ

A full listing of acknowledgments is detailed in the Supplementary Note.

The authors declare no competing financial interests.

Subjects:

Research Funding:

None declared

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Genetics & Heredity
  • Genome-wide association
  • Multilocus genotype data
  • Common variants
  • Positive selection
  • Sequence variants
  • Human populations
  • Genetic variation
  • Adult obesity
  • FTO gene
  • Risk

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

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Journal Title:

Nature Genetics

Volume:

Volume 45, Number 6

Publisher:

, Pages 690-+

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations. © 2013 Nature America, Inc. All rights reserved.

Copyright information:

© 2013 Nature America, Inc. All rights reserved.

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