73 Views | 51 Downloads
Correspondence: larry.mcintire@bme.gatech.edu or cheng.zhu@bme.gatech.edu
Author contributions: C.-y.L. initiated the project; C.-y.L., S.G.E., S.O., P.A.R., C.Z., and L.V.M. designed research; C.-y.L. conducted the AFM experiments; J.L. performed the SMD simulations; K.-k.W. and M.M. generated and purified the yeast actin mutants; K.-k.W., M.M., and P.A.R. contributed new reagents/analytic tools; C.-y.L. and J.L. analyzed data; and C.-y.L., J.L., S.G.E., S.O., S.C., P.A.R., C.Z., and L.V.M. wrote the paper.
Acknowledgements: We thank V. M. Fowler for reagents and F. Kong for help with AFM.
Disclosures: The authors declare no conflict of interest.
This work was supported by National Institutes of Health Grants HL18672 and HL70537 (to L.V.M.); HL091020, HL093723, AI077343, and AI044902 (to C.Z.); AR48615 (to S.O.); and DC8803 (to P.A.R.); and by National Natural Science Foundation of China Grants 31070827, 31222022, and 81161120424 (to J.L.).
The computational resources for the SMD simulations were provided by National Science Foundation Teragrid Large Resource Allocations Committee Grant MCA08X014 (to C.Z.) and by the Supercomputing Center of Chinese Academy of Sciences and National Supercomputing Center Tianjin Center (J.L.).
© 2013 National Academy of Sciences.