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Author Notes:

Correspondence: Brian R. Noga, bnoga@miami.edu

All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.

To the always helpful Frontiers team, whose organizational skills and understanding made possible this Research Topic. We would like to thank the authors and reviewers for their contributions to this Research Topic.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


Research Funding:

None declared


  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • spinal cord
  • neuromodulation
  • monoamines
  • descending and segmental pathways
  • sensorimotor systems
  • locomotion
  • spinal cord injury
  • pain

Editorial: Neuromodulatory Control of Spinal Function in Health and Disease


Journal Title:

Frontiers in Neural Circuits


Volume 13


, Pages 84-84

Type of Work:

Article | Final Publisher PDF


The classical ionotropic transmitters glutamate/ACh (acetylcholine) and glycine/GABA (gamma-amino butyric acid) are, respectively, responsible for the primary excitatory and inhibitory synaptic actions within spinal cord anatomical circuits, be they simple reflexes as the monosynaptic stretch reflex (and its reciprocal inhibition of antagonists), or more distributed and integrated networks along autonomic, sensory, and motor systems. The selection and complex spatiotemporal recruitment of intrinsic spinal circuits (e.g., locomotion) are profoundly sculpted by neuromodulation acting both at pre- and post-synaptic levels.

Copyright information:

© 2020 Noga, Hochman and Hultborn.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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