243 Views | 265 Downloads
Jin-Tang Dong, Email: dongjt@sustech.edu.cn
B.Z. designed and performed most experiments, analyzed the data, and wrote the manuscript; Q.W. and C.F. performed RNA-Seq and ChIP-Seq experiments; Y.L., B.B., L.B., P.M.V., H.R.C., and J.K. performed bioinformatic analyses; L.X., X.L., D.W., W-P.Q., L.Y., and S.X. performed some of the animal experiments; J.C., O.K., and W.Z. helped with some experimental designs; A.O.O. conducted pathological analyses; Y.Z. and M.L. performed some experiments; and J.D. conceived the project, designed and supervised the study, analyzed the data, provided overall guidance, and revised and finalized the manuscript.
We thank Dr. Anthea Hammond of Emory University for editing the manuscript. We thank Dr. Dezhi Wang at the Pathology Core Research Lab in the Department of Pathology of University of Alabama at Birmingham for processing bone tissues. We thank Ms. Lingwei Xiang from ICF for statistical input in data analysis.
The authors declare no competing interests.
This work was supported by grant W81XWH-18-1-0526 from Department of Defense Prostate Cancer Research Program, grant R01CA171189 from the National Institutes of Health, and grant 81130044 from the National Natural Science Foundation of China. The research reported in this publication was supported in part by the Integrated Cellular Imaging Core Facility, the Research Pathology Core Laboratory, and the Emory Integrated Genomics Core of Emory University Winship Cancer Institute under NIH/NCI award number P30CA138292. The tissue microarray of bone metastasis samples from PCa patients in this work is from the Prostate Cancer Biorepository Network (PCBN) supported by the Department of Defense Prostate Cancer Research Program Awards W81XWH-18-2-0013, W81XWH-18-2-0015, W81XWH-18-2-0016, W81XWH-18-2-0017, W81XWH-18-2-0018, and W81XWH-18-2-0019.
© The Author(s) 2021