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Correspondence: Stella T. Chou, The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Research Center, Room 316D, Philadelphia, PA 19104; e-mail: chous@email.chop.edu.
Contribution: S.T.C., J.M.F., R.E.W., and C.M.W. designed the study, analyzed results, and wrote the manuscript; S.V. conducted research and analyzed results; N.L.C.L. was the SWiTCH transfusion consultant; R.C.B. enrolled patients and collected data for the SWiTCH study; and N.L.C.L. and R.C.B. edited the manuscript.
The authors thank the patients and families who enrolled in the studies, members of the Immunohematology and Genomics Laboratory at the New York Blood Center, the Human Genome Sequencing Centre at Baylor College of Medicine for assistance in generating the whole-exome sequencing data, and Perry Evans for statistical support.
The authors declare no competing financial interests.
This work was supported by the Doris Duke Innovations in Clinical Research Award grants 2013151 (S.T.C., C.M.W., and R.E.W.), 2011097, and 2015133 (S.T.C. and C.M.W.);
National Institutes of Health (NIH) National Human Genome Research Institute award U54-HGOO3273 (R.E.W.);
NIH National Heart, Lung, and Blood Institute award HL-078787 for the SWiTCH study (R.E.W.);
And in part by a donation from the DiGaetano family (S.T.C.).
© 2017 by The American Society of Hematology.