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Correspondence: Anna M. M. Boers, PhD, Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, location AMC, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands (amm.boers@gmail.com)
Author Contributions: Drs Boers and Brown had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Boers, Compagne, Albers, Menon, Mitchell, Demchuk, Campbell, Hill, Marquering, Majoie.
Acquisition, analysis, or interpretation of data: Boers, Jansen, S. Brown, Lingsma, Beenen, Devlin, Román, Heo, Ribó, Almekhlafi, Liebeskind, Teitelbaum, Cuadras, du Mesnil de Rochemont, Beaumont, M. Brown, Yoo, Donnan, Mas, Oppenheim, Dowling, Moulin, Agrinier, Lopes, Aja Rodríguez, Al-Ajlan, Madigan, Albers, Soize, Blasco, Davis, Nogueira, Dávalos, Menon, van der Lugt, Muir, Roos, White, Demchuk, van Zwam, Jovin, van Oostenbrugge, Dippel, Campbell, Guillemin, Bracard, Hill, Goyal, Marquering, Majoie.
Drafting of the manuscript: Boers, Albers, Marquering.
Critical revision of the manuscript for important intellectual content: Jansen, S. Brown, Lingsma, Beenen, Devlin, Román, Heo, Ribó, Almekhlafi, Liebeskind, Teitelbaum, Cuadras, du Mesnil de Rochemont, Beaumont, M. Brown, Yoo, Donnan, Mas, Oppenheim, Dowling, Moulin, Agrinier, Lopes, Aja Rodríguez, Compagne, Al-Ajlan, Madigan, Albers, Soize, Blasco, Davis, Nogueira, Dávalos, Menon, van der Lugt, Muir, Roos, White, Mitchell, Demchuk, van Zwam, Jovin, van Oostenbrugge, Dippel, Campbell, Guillemin, Bracard, Hill, Goyal, Marquering, Majoie.
Statistical analysis: Boers, Jansen, S. Brown, Lingsma, Yoo, Agrinier, Compagne, Dippel.
Obtained funding: Aja Rodríguez, Albers, Muir, Mitchell, Demchuk, Jovin, van Oostenbrugge, Campbell, Hill, Goyal, Marquering, Majoie.
Administrative, technical, or material support: Liebeskind, du Mesnil de Rochemont, Beaumont, Aja Rodríguez, Nogueira, Menon, White, van Zwam, Campbell, Goyal, Marquering.
Study supervision: Heo, Almekhlafi, du Mesnil de Rochemont, Donnan, Dowling, Moulin, Lopes, Albers, Blasco, Roos, Mitchell, Demchuk, van Zwam, Hill, Goyal, Marquering, Majoie.
Disclosures: Drs Boers, Jansen, Marquering, and Majoie are shareholders of Nico.lab, a company that focuses on the use of artificial intelligence for medical image analysis. Dr Scott Brown acts as a consultant for Medtronic.
Dr Donnan has received grants from the Australian National Health and Medical Research Council, nonfinancial support from Boehringer Ingelheim, and has served on the advisory boards of Boehringer Ingelheim, AstraZeneca, Bristol-Myers Squibb, and Merck Sharp and Dohme.
Dr Albers holds equity and has consulted for iSchemaView and Medtronic. Dr Davis has received lecture fees from Covidien (Medtronic). Dr Dávalos serves on the advisory board of Medtronic Neurovascular (Steering Committee Solitaire FR Thrombectomy for Acute Revascularization [STAR] trial).
Dr Menon is a member of the steering and executive committee of the Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) trial, which received support from Covidien; a site principal investigator of the Acute Stroke or Transient Ischaemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes (SOCRATES) trial, sponsored by AstraZeneca; a board member of QuikFlo Health; has received honoraria from Penumbra; has provisional patent 62/086077 for triaging systems in ischemic stroke; and has received research funding from the Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Alberta Innovates – Health Solution, Hotchkiss Brain Institute, and the Faculty of Medicine, University of Calgary.
Dr van der Lugt has received honoraria from Stryker as well as unrestricted research grants from Stryker and Penumbra, which were paid to the Erasmus University Medical Center.
Dr Mitchell has received unrestricted grant funding for the Extending the Time for Thrombolysis in Emergency Neurological Deficits–Intra-Arterial (EXTEND-IA) trial to the Florey Institute of Neuroscience and Mental Health from Covidien (Medtronic); has served as an unpaid consultant to Codman Johnson and Johnson; and has received unrestricted research funding and grants from Codman Johnson and Johnson, Medtronic, and Stryker, which were paid to the University of Melbourne.
Dr Demchuk has received grant support and personal fees from Covidien (Medtronic). Dr van Zwam has received honoraria from Stryker, which were paid to the Erasmus University Medical Center.
Dr Jovin has consulted for Codman Neurovascular and Neuravi, holds stock in Silk Road and Blockade, has acted as an unpaid consultant to Stryker as principal investigator of the Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention With Trevo (DAWN) trial, and served as an unpaid member of the advisory board for Medtronic.
Dr Dippel has received honoraria from Stryker, which were paid to the Erasmus University Medical Center, and unrestricted research grants the from Dutch Heart Foundation, AngioCare, Medtronic/Covidien/Ev3, medac/Lamepro, Penumbra, Stryker, Stryker European, and Top Medical/Concentric for the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) and from the Dutch Heart Foundation, Dutch Brain Foundation, Stryker European, Medtronic, and Penumbra for other research, all paid to the Erasmus University Medical Center. Dr Campbell has received research support from the National Health and Medical Research Council of Australia (grants GNT1043242 and GNT1035688), Royal Australasian College of Physicians, Royal Melbourne Hospital Foundation, National Heart Foundation, National Stroke Foundation of Australia, and unrestricted grant funding for the EXTEND-IA trial to the Florey Institute of Neuroscience and Mental Health from Covidien (Medtronic).
Dr Hill has received unrestricted grant funding for the ESCAPE trial to the University of Calgary from Covidien (Medtronic) as well as in-kind support consortium of the Heart and Stroke Foundation, Alberta Innovates Health Solutions, Alberta Health Services, and the University of Calgary (Hotchkiss Brain Institute, Departments of Clinical Neurosciences and Radiology, and Calgary Stroke Program); has received personal fees from Merck; and has received nonfinancial support from Hoffmann-La Roche.
Dr Hill has a patent for systems and methods for assisting in decision making and triaging for patients with acute stroke (62/086077) pending to the US Patent and Trademark Office and owns stock in Calgary Scientific Incorporated, a company that focuses on medical imaging software.
Dr Goyal has received grants and personal fees from Covidien. In addition, Dr Goyal has a patent for systems and methods for diagnosing strokes (PCT/CA2013/000761) licensed to GE Healthcare. Dr Majoie has received speakers’ fees from Stryker, which were paid to the University of Amsterdam.
No other disclosures were reported.
The Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials collaboration was funded by Medtronic through an unrestricted grant to the University of Calgary.
© 2018 2018 American Medical Association. All rights reserved.