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Correspondence: Nicole Frahm, PhD, Bill & Melinda Gates Medical Research Institute, 245 Main Street, Cambridge, MA 02142, nicole.frahm@gatesmri.org
Author contributions: E.G.K, L.R.B., M.A., J.H., B.S.G., J.K., P.A.G., R.P.J. designed research; N.G. contributed to study design, protocol development, implementation management and safety data monitoring; B.M. conducted the epitope mapping assays;
C.Y. and Y.H performed the statistical analyses and generated tables and figures. G.P., M.C., J.V., M.S. and H.V.T. enrolled participants. All authors contributed to discussions about the results and critically revised the manuscript. N.F. wrote the manuscript. P.B.G, L.C. and M.J.M. supervised the research.
We thank the HVTN 084 study volunteers; the staff and community members at each of the study sites; the staff at the HVTN Administrative Core and SCHARP Statistical Center. We thank Steve Self for his statistical leadership in the design of this study and Hasan Ahmed for his statistical analysis support.
We thank Stephen De Rosa and Kristen Cohen for technical expertise and oversight; Terri Stewart, Kevin Hawkins, Aaron Seese and Paul Newling for technical assistance, Carol Marty for data management and Michael Stirewalt for quality assurance oversight.
Disclosures: The authors declare that they have no competing interests.
This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID) U.S. Public Health Service Grants UM1 AI068614 [LOC: HIV Vaccine Trials Network], UM1 AI068635 [SDMC: HIV Vaccine Trials Network], UM1 AI068618 [LC: HIV Vaccine Trials Network]
UM1 AI069481 [Seattle-Lausanne-Kampala Clinical Trials Unit: Centre Hospitalier Universitaire Vaudois Clinical Research Site], UM1 AI069412 [Harvard/Boston/Providence Clinical Trials Unit: Brigham and Women’s Hospital Clinical Research Site]
UM1 AI069438 [IMPACTA Peru Clinical Trials Unit: Asociación Civil Impacta Salud y Educacion (IMPACTA) and Asociación Civil Selva Amazonica (ACSA) Clinical Research Sites], UM1 AI069420 [São Paulo Clinical Trials Unit: Centro de Referência e Treinamento DST/AIDS Clinical Research Site]
UM1 AI069470 [Columbia Partnership for Prevention and Control of HIV/AIDS Clinical Trials Unit: College of Physicians & Surgeons and New York Blood Center Clinical Research Sites], and P51 OD011132.
© 2019 The Authors.