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Author Notes:

Correspondence: Dr. Eleza Golden, Northside Radiology Associates 5775 Glendridge Dr #525 Atlanta, GA 30328. E-mail: egolden@northsideradiology.com

There are no conflicts of interest.


Research Funding:



  • Neonate
  • neonatal imaging
  • subcutaneous fat necrosis

Brown fat necrosis with calcifications in the newborn: Risk factors, radiographic findings, and clinical course


Journal Title:

Indian Journal of Radiology and Imaging


Volume 28, Number 1


, Pages 107-110

Type of Work:

Article | Final Publisher PDF


Objective: To describe the radiographic appearance of subclinical calcified brown fat necrosis and the associated clinical and laboratory findings. Materials and Methods: Picture Archiving and Communications Sytem (PACS) was searched using keywords 'soft tissue calcification' and 'chest.' The clinical record was searched for prior cardiac surgery, bypass, Extracorporeal Membrane Oxygentation (ECMO) and prostaglandin use. Age when calcifications were first detected, location, resolution, and associated laboratory abnormalities were recorded. Results: Nine patients were identified. None had skin lesions. All patients had congenital heart disease and had experienced cardiac/respiratory arrest and/or severe hypotension 1-6 weeks before soft tissue calcifications occurred. Calcifications resolved by 9 weeks to 5 months in 3 patients. The remaining were either deceased or lacked follow-up imaging. Renal ultrasound was performed in all but 1 patient. Nephrocalcinosis was only seen in 1 patient. Conclusion: Brown fat necrosis is subclinical, diagnosed on plain film, and likely self-limited. It occurs in term and preterm infants who have undergone significant systemic stress and carries a poor prognosis.

Copyright information:

© 2018 Indian Journal of Radiology and Imaging Published by Wolters Kluwer - Medknow.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/).
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