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Author Notes:

Delynn M. Moss, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Building 23, Room 10-107, Atlanta, GA 30329. E-mail: dmm3@cdc.gov

We would like to thank the parents, students, and teachers who allowed us to conduct this work, as well as the Government of Mali. We would also like to thank the research team, including Abdoulaye Sow, Seydou Samaké, Salif Ismaïla Traoré, Fatoumata Habib Traoré, Karim Diamoutene, Yacouba Sogore, Alpha Oumar Haidara, as well as Niélé Hawa Diarra and Samba Diop from the University of Bamako. Thanks as well to the UNICEF, WaterAid, CARE, Oxfam, and Save the Children teams for their support, specifically Jérémie Toubkiss, Yagouba Diallo, Seydou Niafo, Touréba Keïta, Assitan Sogoré, Salimata Togola, Fatoumata Haïdara, Mamadou Diallo, Zoumana Cissé, Ousmane Haïdara, and Thierno Bocoum. We thank Tom Nutman for providing the Wb123 antigen.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Public, Environmental & Occupational Health
  • Tropical Medicine
  • ELIMINATE LYMPHATIC FILARIASIS
  • WUCHERERIA-BANCROFTI
  • GLOBAL PROGRAM
  • QUANTITATION
  • ASSAY
  • DRUG
  • ANTIBODIES
  • IMPACT
  • TOOLS
  • SERUM

Serological Responses to Filarial Antigens in Malian Children Attending Elementary Schools

Tools:

Journal Title:

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Volume:

Volume 96, Number 1

Publisher:

, Pages 229-232

Type of Work:

Article | Final Publisher PDF

Abstract:

Dried blood spots (DBS) were collected from 805 children attending 42 elementary schools in the regions of Mopti, Sikasso, Koulikoro, and the regional capital of Bamako in Mali as part of an evaluation of a school health intervention. Eluted immunoglobulin (Ig) G from the DBS was assessed by a multiplex bead assay (MBA) for two filariasis antigens, Wuchereria bancrofti, Wb123, and Brugia malayi, Bm14, to determine the effectiveness of mass drug administration (MDA) programs to eliminate lymphatic filariasis (LF). The prevalence of positive IgG responses in the children to each antigen was less than 1%, indicating effectiveness of the MDA against LF. The MBA is an excellent serological platform that provides cost-effective opportunities to evaluate public health activities beyond the survey targets.

Copyright information:

© Copyright 2017 by The American Society of Tropical Medicine and Hygiene.

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