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Author Notes:

wendy-maury@uiowa.edu

Conceptualization, K.J.R., N.S.B., and W.M.; Methodology, K.J.R., O.S., R.V., C.J.J., M.R.G., N.S.B., and W.M.; Investigation, K.J.R., O.S., R.V., and L.N.M.; Writing - Original Draft, K.J.R.; Writing - Review & Editing, K.J.R., O.S., R.V., C.J.J., M.R.G., N.S.B., and W.M.; Funding Acquisition, N.S.B. and W.M.; Resources, N.S.B. and W.M.; Supervision, W.M.

The authors declare no competing interests.

Subjects:

Research Funding:

This study was supported by AI139902 to W.M. N.S.B. also was supported by the NIH grant numbers AI125446 and AI127481. M.R.G. and C.J.J. were supported by NIH/NIAID contract number HHSN272201200031C and NIH Office of Research Infrastructure Programs/OD P51OD011132. K.J.R. was supported by NIH training grants T32 GM007337 and T32 GM 067795. Analyses were confirmed by the Institute for Clinical and Translational Science Biostatistics Core that was supported by NIH UL1TR002537.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Cell Biology
  • IMMUNE-RESPONSES
  • SIERRA-LEONE
  • MOUSE MODEL
  • B-CELLS
  • MALARIA
  • PROTECTION
  • PATHOGENESIS
  • CYTOKINES
  • SURVIVAL
  • CHABAUDI

Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection

Tools:

Journal Title:

CELL REPORTS

Volume:

Volume 30, Number 12

Publisher:

, Pages 4041-+

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Rogers et al. demonstrate that acute Plasmodium infection protects against lethal Ebola virus challenge. Protection is conferred by Plasmodium-elicited interferon gamma (IFN-γ) that causes M1 polarization of tissue macrophages. These studies provide insight into conflicting clinical data regarding whether malaria protects or sensitizes hosts to Ebola virus.

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© 2020 The Authors

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