About this item:

127 Views | 88 Downloads

Author Notes:

Unjali Gujral, MPH, PhD, Emory Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, 1518 Clifton Road, Room 7040-L, Emory University, Atlanta, GA, USA, Phone: (626) 589-8512, ugujral@emory.edu

U.P.G. analyzed data, wrote the manuscript, drafted tables and figures, and revised the manuscript and approved the final manuscript for submission.

K.M.V.N. contributed to concept, design, analysis, and interpretation of the data, reviewed and revised the manuscript, and approved the final manuscript for submission.

R.P. and M.D oversaw the CARRS research operations and contributed to the design, and data collection of the CARRS study.

R.M.A contributed to the discussion and interpretation of the data, reviewed and revised the manuscript, and approved the final manuscript for submission.

M.V. contributed to the discussion and interpretation of the data, reviewed and revised the manuscript, and approved the final manuscript for submission.

U.P.G. is the guarantor of this work and has had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

The authors have no conflicts of interest.

Subjects:

Research Funding:

The CARRS Study was funded in part by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services, under Contract No. HHSN268200900026C, and the United Health Group, Minneapolis, MN, USA., KMV Narayan was funded in part by the National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health under Award Number P30DK111024.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Endocrinology & Metabolism
  • Type 2 diabetes
  • Asian Indian
  • Ethnicity
  • Underweight
  • Normal weight
  • Body mass index
  • NUTRITION TRANSITION
  • RISK
  • US
  • OVERWEIGHT
  • OBESITY
  • INDIA
  • CHINA

Ethnic differences in the prevalence of diabetes in underweight and normal weight individuals: The CARRS and NHANES studies

Tools:

Journal Title:

DIABETES RESEARCH AND CLINICAL PRACTICE

Volume:

Volume 146

Publisher:

, Pages 34-40

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Aims: Type 2 diabetes in lean individuals has recently come to attention. We assessed type 2 diabetes prevalence and the associated risk factors in underweight and normal weight individuals in two ethnic populations. Methods: We conducted cross-sectional analyses, using representative samples of 4930 Asian Indians from the CARRS-Chennai Study and 2868 Whites from the NHANES Survey. Diabetes was defined as use of glucose lowering medication, fasting glucose ≥126 mg/dl, or 2 h glucose ≥200 mg/dl. Body mass index (BMI) was classified using WHO standard criteria. Results: Prevalence of type 2 diabetes by BMI varied by ethnicity and sex. In men, type 2 diabetes prevalence was 5.4% and 23.5% in underweight and normal weight Asian Indians and 0.0% and 6.1% in underweight and normal weight Whites. In women, the prevalence was 5.6% and 13.6% in underweight and normal weight Asian Indians and 2.3% and 2.8% in underweight and normal weight Whites. Adjustment for waist circumference, insulin resistance, and insulin secretion did not explain the increased prevalence in Asian Indians. Conclusions: These findings suggest significant ethnic differences in type 2 diabetes prevalence without overweight or obesity. Future studies should examine the pathophysiology of type 2 diabetes development in lean individuals.

Copyright information:

© 2018 Elsevier B.V.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Export to EndNote