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Author Notes:

Eric Prince, Email: eric.prince@cuanschutz.edu

See publication for full list of authors.

Primary Authors: EP, RW.

Analysis and Interpretation of Data: EP.

Experimental Design: TCH.

Experimental Implementation: RW, AD, SS, AH, TV, CA.

Internal Reviewers/Editors: KL, NF, MH, TCH.

Advancing Treatment for Pediatric Craniopharyngioma (ATPC) Consortium Members: JJ, LM, RA, MS, RN, DL, GG, TN, RD, LK, EJ, GJ, KG, AS, JC, AL, AD, MK, TCH.

The author(s) read and approved the final manuscript.

The authors wish to express their gratitude for study coordinators Anastasia Arynchna (University of Alabama Birmingham), Kari Bollerman (Miami Children’s Hospital), Stephen Gannon (Vanderbilt University), Lisa Tetreault (Johns Hopkins All Children’s Hospital), Corrine Gardner (Washington University St. Louis), Kris Laurence (Children’s Mercy Hospital), Anthony Bet (Stanford University), Hannah Goldstein (Columbia University), and Kaitlin Hardy (Children’s National Medical Center) for their assistance in making this study possible.

The authors declare they have no competing interests.

Subject:

Research Funding:

The authors wish to acknowledge The Brain Tumor Charity for funding which made this work possible (GN-000522 (181477)).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • Adamantinomatous Craniopharyngioma
  • Transcriptional analysis
  • Age-related therapy
  • Pediatric Craniopharyngioma
  • Suprasellar tumor

Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets

Tools:

Journal Title:

Acta Neuropathologica Communications

Volume:

Volume 8, Number 1

Publisher:

, Pages 68-68

Type of Work:

Article | Final Publisher PDF

Abstract:

Adamantinomatous craniopharyngioma (ACP) is a biologically benign but clinically aggressive lesion that has a significant impact on quality of life. The incidence of the disease has a bimodal distribution, with peaks occurring in children and older adults. Our group previously published the results of a transcriptome analysis of pediatric ACPs that identified several genes that were consistently overexpressed relative to other pediatric brain tumors and normal tissue. We now present the results of a transcriptome analysis comparing pediatric to adult ACP to identify biological differences between these groups that may provide novel therapeutic insights or support the assertion that potential therapies identified through the study of pediatric ACP may also have a role in adult ACP. Using our compiled transcriptome dataset of 27 pediatric and 9 adult ACPs, obtained through the Advancing Treatment for Pediatric Craniopharyngioma Consortium, we interrogated potential age-related transcriptional differences using several rigorous mathematical analyses. These included: canonical differential expression analysis; divisive, agglomerative, and probabilistic based hierarchical clustering; information theory based characterizations; and the deep learning approach, HD Spot. Our work indicates that there is no therapeutically relevant difference in ACP gene expression based on age. As such, potential therapeutic targets identified in pediatric ACP are also likely to have relvance for adult patients.

Copyright information:

© 2020 The Author(s).

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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