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Author Notes:

Jessica M Sales, Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, 1518 Clifton Road, Room 570, Atlanta, GA, 30322, United States, Phone: 1 404 727 6598, Email: jmcderm@emory.edu

The authors would like to thank the ATN, NICHD, and the Emory and ATN Coordinating Center teams for their work in developing this protocol study.

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conflicts of Interest: JMS and ANS receive grants from Gilead Sciences.


Research Funding:

The ATN is funded by the National Institutes of Health through the Eunice Kennedy Shriver National Institute of Child Health and Human Development with supplemental funding from the National Institute of Mental Health, the National Institute on Drug Abuse, and the National Institute on Minority Health and Health Disparities.

This research was supported by the National Institutes of Health grant 5U24HD089880.


  • HIV
  • implementation science
  • pre-exposure prophylaxis
  • women's health

Pre-exposure prophylaxis integration into family planning services at title X clinics in the southeastern United States: A geographically-targeted mixed methods study (Phase 1 ATN 155)

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Journal Title:

JMIR Research Protocols


Volume 8, Number 6


, Pages e12774-e12774

Type of Work:

Article | Final Publisher PDF


Background: Black adolescent and young adult women (AYAW) in the Southern United States are disproportionately affected by HIV. Pre-exposure prophylaxis (PrEP) is an effective, scalable, individual-controlled HIV prevention strategy that is grossly underutilized among women of all ages and requires innovative delivery approaches to optimize its benefit. Anchoring PrEP delivery to health services that AYAW already trust, access routinely, and deem useful for their sexual health may offer an ideal opportunity to reach women at risk for HIV and to enhance their PrEP uptake and adherence. These services include those of family planning (FP) providers in high HIV incidence settings. However, PrEP has not been widely integrated into FP services, including Title X-funded FP clinics that provide safety net sources of care for AYAW. To overcome potential implementation challenges for AYAW, Title X clinics in the Southern United States are uniquely positioned to be focal sites for conceptually informed and thoroughly evaluated PrEP implementation science studies. Objective: The aim of this study is to assess inner and outer context factors (barriers and facilitators) that may influence the adoption of PrEP prescription and treatment services in Title X clinics serving AYAW in the Southern United States. Methods: Phase 1 of Planning4PrEP is an explanatory sequential, mixed methods study consisting of a geographically-targeted Web-based survey of Title X clinic administrators and providers in the Southern United States, followed by key informant interviews among a purposively selected subset of responders to more comprehensively assess inner and outer context factors that may influence adoption and implementation of PrEP in Title X FP clinics in the South. Results: Phase 1 of Planning4PrEP research activities began in October 2017 and are ongoing. To date, survey and key informant interview administration is near completion, with quantitative and qualitative data analysis scheduled to begin soon after data collection completion. Conclusions: This study seeks to assess inner and outer contextual factors (barriers and facilitators) that may influence the adoption and integration of PrEP prescription and treatment services in Title X clinics serving AYAW in the Southern United States. Data gained from this study will inform a type 1 hybrid effectiveness implementation study, which will evaluate the multilevel factors associated with successful PrEP implementation while evaluating the degree of PrEP uptake, continuation, and adherence among women seen in Title X clinics.

Copyright information:

©Jessica M. Sales, Cam Escoffery, Sophia A. Hussen, Lisa B. Haddad, Ashley Phillips, Teresa Filipowicz, Maria Sanchez, Micah McCumber, Betty Rupp, Evan Kwiatkowski, Matthew A. Psioda, Anandi N. Sheth.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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