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Correspondence: Sabina Rinaldi, Email:rinaldis@iarc.fr

I.R., S.R., G.T.M., G.I.S., C.P., A.C.Ro., M.L.G. and P.L.P. designed the study.

G.T.M., A.A.L., I.A.C., G.I.S., M.B., C.P., A.C.Ro. and M.L.G. collected the data and sample materials.

P.L.P. and M.O. designed the specific protocols for IHC and genetic analyses.

P.L.P., M.O. and M.G.L. conducted molecular analyses.

C.B. assembled the database.

M.H. analyzed the data.

M.H., I.R., S.R., G.T.M., G.I.S., C.P., A.C.Ro., M.L.G. and M.J.G. interpreted the data.

All authors participated in writing the manuscript.

All authors read and approved the final manuscript.

The author wish to thank the substantial support provided by the research nurses and health workers as well as Tracy Lignini, Dacia Cristin, Cecile Le Duc, Jordi de Battle, and Talita Duarte-Salles, Ana Cristina Ocampo for the logistic and data basis development, and Vivian Viallon, who provided statistical support.

The authors also wish to thank the women participating in the project, for their time and commitment.

The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

Ana Cecilia Rodriguez was part of the Proyecto Guanacaste when this work was carried out.

The authors declare no competing interests.

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Research Funding:

The study is funded by the International Agency for Research on Cancer (IARC), the Union for International Cancer Control (UICC), the Pan American Health Organization (PAHO), the Ibero-American Programme for the Development of Science and Technology (CYTED), COLCIENCIAS (grant n°1115–569–348899), Universidad de Antioquia (grants CPT-1801, SIIU-2019–25272 and Estrategia de Sostenibilidad 2013–2014 to Group Infection and Cancer).

For MH, the work reported in this paper was undertaken during the tenure of a postdoctoral fellowship awarded by the International Agency for Research on Cancer, financed by La Ligue contre le cancer.

Keywords:

  • breast cancer
  • cancer epidemiology
  • cancer prevention
  • risk factors

Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study

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Scientific Reports

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Volume 10

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Article | Final Publisher PDF

Abstract:

Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20–45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89–0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69–0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67–0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47–8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98–1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.

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Copyright © The Author(s) 2020

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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