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Author Notes:

Correspondence: Christina L. Hutson or Inger K. Damon, chutson1@cdc.gov or iad7@cdc.gov

Processed and ran molecular assays; CC.

Conceived and designed the experiments: CLH NGR DC VAO KLK IKD.

Performed the experiments: CLH NGR DC CC JSS.

Analyzed the data: CLH CH TN VAO IKD.

Contributed reagents/materials/analysis tools: TN.

Wrote the paper: CLH NGR DSC JSS TN CH VAO KLK IKD.

Competing Interests: The authors have declared that no competing interests exist.

Subject:

Research Funding:

The authors have no support or funding to report.

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • ANIMAL-MODEL
  • RISK-FACTORS
  • CONGO BASIN
  • DISEASE
  • INFECTION
  • PATHOLOGY
  • STRAINS
  • AFRICAN
  • HUMANS

Transmissibility of the Monkeypox Virus Clades via Respiratory Transmission: Investigation Using the Prairie Dog-Monkeypox Virus Challenge System

Tools:

Journal Title:

PLOS One

Volume:

Volume 8, Number 2

Publisher:

, Pages e55488-e55488

Type of Work:

Article | Final Publisher PDF

Abstract:

Monkeypox virus (MPXV) is endemic within Africa where it sporadically is reported to cause outbreaks of human disease. In 2003, an outbreak of human MPXV occurred in the US after the importation of infected African rodents. Since the eradication of smallpox (caused by an orthopoxvirus (OPXV) related to MPXV) and cessation of routine smallpox vaccination (with the live OPXV vaccinia), there is an increasing population of people susceptible to OPXV diseases. Previous studies have shown that the prairie dog MPXV model is a functional animal model for the study of systemic human OPXV illness. Studies with this model have demonstrated that infected animals are able to transmit the virus to naive animals through multiple routes of exposure causing subsequent infection, but were not able to prove that infected animals could transmit the virus exclusively via the respiratory route. Herein we used the model system to evaluate the hypothesis that the Congo Basin clade of MPXV is more easily transmitted, via respiratory route, than the West African clade. Using a small number of test animals, we show that transmission of viruses from each of the MPXV clade was minimal via respiratory transmission. However, transmissibility of the Congo Basin clade was slightly greater than West African MXPV clade (16.7% and 0% respectively). Based on these findings, respiratory transmission appears to be less efficient than those of previous studies assessing contact as a mechanism of transmission within the prairie dog MPXV animal model.

Copyright information:

This is an Open Access work distributed under the terms of the Creative Commons Universal : Public Domain Dedication License (https://creativecommons.org/publicdomain/zero/1.0/).
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