Pulmonary vein remodeling following atrial fibrillation ablation: Implications for the radiographic diagnosis of pulmonary vein stenosis

• Authors: Faisal Merchant, Emory University; Mathew R. Levy, Emory University; Shahriar Iravanian, Emory University; Ramal M. Weragoda, Emory University; Edward C. Clermont, University of Pennsylvania; Heval M. Kelli, Emory University; Robert Eisner, Emory University; David Vadnais, Emory University; Mikhael El Chami, Emory University; Angel Leon, Emory University; David De Lurgio, Emory University
• Journal Title: Journal of Atrial Fibrillation
• Volume: Volume 9, Number 2
• Publisher: JAFIB | 2016-08-01, Pages 23-28
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.4022/jafib.1453
• Subjects: Health Sciences, Medicine and Surgery
• Keywords: Ablation; Atrial Fibrillation; Cardiac Magnetic Resonance; Pulmonary Vein Stenosis; Pulmonary Veins

Abstract

Background: Pulmonary vein (PV) reverse remodeling has been recognized following atrial fibrillation (AF) ablation. However, the extent of physiologic reverse remodeling after AF ablation and the potential impact of reverse remodeling on the radiographic diagnosis of PV stenosis have not been well characterized. Methods: From January 2004 to February 201 186 patients underwent paired cardiac magnetic resonance imaging (MRI) to delineate PV orifice dimensions before and after (mean 109 ± 61 days) an initial AF ablation. Results: Negative remodeling of the PV orifice cross sectional area occurred in 67.8% of veins with a mean reduction in area of 21.0 ± 14.1%, and positive remodeling was seen in the remaining PVs with an increase in area of 22.1 ± 23.4% compared to baseline. No PVs demonstrated a reduction in cross-sectional area of < 75% (maximum reduction observed was 58%). Negative remodeling of the PV long axis dimension was observed in 55.2% of veins with a mean reduction of 14.6 ± 9.2% compared to pre-ablation and positive remodeling was observed in 25.3% of PVs with a mean increase in diameter of 14.7 ± 12.6%. Only 1 PV demonstrated a reduction in orifice diameter of < 50%. There were no clinically evident or suspected cases of PV stenosis in this cohort. Conclusions: Negative remodeling of the PV orifice area was noted in the majority of PVs following AF ablation. However, in almost all cases, the extent of negative remodeling was well below commonly used thresholds for the radiographic diagnosis of PV stenosis.