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Author Notes:

Corresponding author: Eric Hunter, Tel.: 404-727-8587; fax: 404-727-9316. ehunte4@emory.edu

The investigators thank all the volunteers in Zambia and Rwanda who participated in this study and all the staff in the Rwanda Zambia HIV Research Group who made this study possible.

The investigators would like to thank Jon Allen and Paul Farmer for technical assistance, sample management, and database management.

SC was in receipt of training support through the Molecules to Mankind pathway at Emory University, funded as an Institutional Program Unifying Population and Laboratory Based Sciences by the Burroughs Wellcome Fund. EH is a Georgia Eminent Scholar.

Subjects:

Research Funding:

This study was funded by R01 MH095503–05 (SA), R37 AI51231 and R01 AI64060 (E.H.).

This work was also supported, in part, by the Virology Core at the Emory Center for AIDS Research by performing viral load determinations (grant P30 AI050409); the Yerkes National Primate Research Center base grant through the Office of Research Infrastructure Programs/OD P51OD11132.

This study is supported in part by IAVI (SA), whose work is made possible by generous support from many donors including: the Bill & Melinda Gates Foundation; the Ministry of Foreign Affairs of Denmark; Irish Aid; the Ministry of Finance of Japan; the Ministry of Foreign Affairs of the Netherlands; the Norwegian Agency for Development Cooperation (NORAD); the United Kingdom Department for International Development (DFID), and the United States Agency for International Development (USAID).

The full list of IAVI donors is available www.iavi.org.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Virology
  • HIV
  • Human Fc-gamma receptors
  • Fc gamma RIIA
  • Fc gamma RIIIA
  • Acquisition
  • HIV disease progression
  • Subtype A
  • Subtype C
  • Rwanda
  • Zambia
  • CELLS
  • IGG
  • TRANSMISSION
  • POLYMORPHISM
  • INFECTION
  • GENOTYPE
  • COUNTS
  • VIRUS

Fc-gamma receptor IIA and IIIA variants in two African cohorts: Lack of consistent impact on heterosexual HIV acquisition, viral control, and disease progression

Tools:

Journal Title:

VIROLOGY

Volume:

Volume 525

Publisher:

, Pages 132-142

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Human Fc-gamma receptors (FcγRs) FcγRIIA and FcγRIIIA contain amino acid variants with both high and low affinities for IgG that modulate antibody-mediated effector functions. Recent HIV vaccine trials suggested that these FcγR variants can influence susceptibility to HIV infection, which prompted us to fully assess the role of FcγR variants on HIV acquisition, viral control, and disease progression in two longitudinal heterosexual transmission cohorts with HIV subtypes A and C as the major circulating viruses. For 836 participants, molecular genotyping resolved genetic variations encoding the FcγRIIA (131 H/R) and FcγRIIIA (158 V/F) single nucleotide polymorphisms. Kaplan-Meier curves, Cox proportional hazards models, and linear regression models did not reveal any clear or consistent FcγR association with time to HIV acquisition, viral load in early infection, or extent of CD4 + T-cell decline over time after infection. Overall, previous epidemiological findings on FcγR variants and vaccine efficacy are not readily applicable to heterosexual HIV transmission.

Copyright information:

© 2018 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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