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Author Notes:

See publication for a full list of authors.

Acknowledgments: The authors would like to thank Dr. Michelle M. Mielke for her helpful comments and feedback on early drafts of this manuscript.

Disclosures: L.S.S. reports being an editor on the Cochrane Collaboration Dementia and Cognitive Improvement Group, which oversees systematic reviews of drugs for cognitive impairment and dementia.

LSS also received a grant from the Alzheimer’s Association for a registry for dementia and cognitive impairment trials; he is also in receipt of grant or research support from Baxter, Elan Pharmaceuticals, Johnson & Johnson, Eli Lilly, Myriad, Novartis, and Pfizer. He has served as a consultant for or received consulting fees from Abbott Laboratories, AC Immune, Allergan, Allon, Alzheimer Drug Discovery Foundation, AstraZeneca, Bristol-Myers Squibb, Elan, Eli Lilly, Exonhit, Forest, GlaxoSmithKline, Ipsen Pharmaceuticals, Johnson & Johnson, Lundbeck, Myriad, Medavante, Medivation, Merck, Merz, Novartis, Pfizer, Roche, Sanofi-Aventis, Schering-Plough, Schwabe, Toyama, and Transition Therapeutics.

L.N.G. reports serving on the Phillips Life Line Falls Advisory Board.

D.S.M. is a full time employee of Bracket .

C.G.L has received grant support (research or CME) from NIMH, NIA, Associated Jewish Federation of Baltimore, Weinberg Foundation, Forest, Glaxo-Smith-Kline, Eisai, Pfizer, Astra-Zeneca, Lilly, Ortho-McNeil, Bristol-Myers, Novartis, National Football League, Elan, Functional Neuromodulation Inc.; has served as consultant/advisor for Astra-Zeneca, Glaxo-Smith Kline, Eisai, Novartis, Forest, Supernus, Adlyfe, Takeda, Wyeth, Lundbeck, Merz, Lilly, Pfizer, Genentech, Elan, NFL Players Association, NFL Benefits Office, Avanir, Zinfandel; and received honorarium or travel support from Pfizer, Forest, Glaxo-Smith Kline, and Health Monitor.

Subject:

Research Funding:

Y.E.G. was supported by NIMH grant K01-MH68351, NIA grant U01-AG006786 (the Mayo Clinic Study of Aging), National Center for Research Resources grant RR024150 (Mayo Clinic CTSA [Career Transition Award]), the Robert Wood Johnson Foundation (Harold Amos Scholar), and the European Union Regional Development Fund (Project FNUSA-ICRC: CZ.1.05/1.1.00/02.0123).

L.N.G. was supported by NIMH grants R24-MH074779, R01-MH079814, and RC1-MH090770-01, and Alzheimer’s Association grant IIRG-07-28686;

C.G.L. was supported by the Johns Hopkins Alzheimer’s Disease Research Center (P50-AG005146).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Clinical Neurology
  • Neurosciences & Neurology
  • Neuropsychiatric symptoms
  • Behavioral and psychological symptoms of dementia
  • Agitation/aggression
  • Sleep disorders
  • Depression
  • Apathy
  • Psychosis
  • Delusions
  • Hallucinations
  • Dementia
  • Alzheimer's disease
  • Mild cognitive impairment
  • Mild behavioral impairment
  • MILD COGNITIVE IMPAIRMENT
  • ASSOCIATION WORKGROUPS
  • DIAGNOSTIC GUIDELINES
  • BEHAVIORAL SYMPTOMS
  • NATIONAL INSTITUTE
  • RANDOMIZED-TRIAL
  • DOUBLE-BLIND
  • DEPRESSION
  • DEMENTIA
  • SCALE

Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

Journal Title:

Alzheimers and Dementia

Volume:

Volume 9, Number 5

Publisher:

, Pages 602-608

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.

Copyright information:

© 2013 The Alzheimer¢s Association. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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