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Author Notes:

Correspondence to Kristie A. Blum, MD. Professor of Medicine, Department of Hematology and Medical Oncology, Winship Cancer Institute, 1365 Clifton Road NE, B3233, Emory University, Atlanta, GA 30322. Tel: +1 404-778-5933; Fax: +1 404-778-3366; kablum@emory.edu

KAB, AP, and CRF conceived and designed the study, collected the data, and analysed the data.

KAB wrote the manuscript.

FGK, SC, and CRF reviewed the data and reviewed and edited the manuscript.



  • Science & Technology
  • Life Sciences & Biomedicine
  • Hematology
  • adolescent and young adult
  • Hodgkin lymphoma
  • non-Hodgkin lymphoma
  • Surveillance Epidemiology and End Results
  • epidemiology
  • incidence
  • survival

Incidence and outcomes of lymphoid malignancies in adolescent and young adult patients in the United States


Journal Title:

British Journal of Haematology


Volume 183, Number 3


, Pages 385-399

Type of Work:

Article | Post-print: After Peer Review


Lymphoma incidence and survival in adolescent and young adult (AYA, defined as 15–39 years of age) and adult patients (>39 years) were assessed using Surveillance, Epidemiology, and End Results (SEER) data. From 2000 to 2014, 431 721 lymphoma cases were reported to SEER, 9% in AYA patients. In the AYA group, the highest age-adjusted incidence rate was for classical Hodgkin lymphoma [HL; 3·4 per 100 000 person-years; 95% confidence interval (CI), 3·38–3·49] followed by diffuse large B cell lymphoma (DLBCL; 1·56, 95% CI, 1·53–1·60) and for adults, it was plasma cell neoplasms (14·17, 95% CI, 14·07–14·27), DLBCL (13·86, 95% CI, 13·76–13·96) and chronic lymphocytic leukaemia (CLL; 13·19, 95% CI, 13·09–13·29). HL comprised 42% of lymphoma cases for AYAs, but only 4% in adults. The occurrence of DLBCL among AYAs and adults was similar, 18% and 20%, respectively. Twenty-eight percent of AYAs compared with 9% of adults presented with stage II disease, and 21% of AYAs compared with 10% of adults had B-symptoms. Extranodal disease was less common (33%) in AYAs than adults (59%). Overall, AYA patients with lymphoma have better 2- and 5-year relative survival rates (RSRs) compared to adults. When restricted to HL and DLBCL, RSR of AYA patients exceeds adult RSR.

Copyright information:

© 2018 British Society for Haematology and John Wiley & Sons Ltd

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