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Correspondence to Jeremy M. Boss, jmboss@emory.edu, or Iñaki Sanz, ignacio.sanz@emory.edu
Author contributions: C.D.S. and E.L.B. designed and performed experiments, analyzed the data, and wrote the manuscript.
B.G.B. and T.M. analyzed data.
D.G.P. performed ATAC-seq.
S.A.J. performed PD-1 and ATF3 phenotyping.
T.D., K.S.C, and S.L.H. sorted and prepared cDNA for validation cohorts.
B.E.N., E.-H.L., and C.W. provided cell sorting, biobanking expertise, and sample preparation.
A.K. evaluated cohort clinical data.
I.S. and J.M.B. designed experiments, wrote the manuscript, and oversaw the project.
We thank the members of the Boss and Sanz laboratories for critical reading of the manuscript, the New York University Genome Technology Center for Illumina sequencing, the Yerkes Genomics Core for RNA-seq library preparation, the Emory Pediatrics Flow Cytometry core for FACS isolation of cell subsets, and the Emory Integrated Genetics and Computational Core for Bioanalyzer and sequencing library QC.
The authors declare no competing interests.
This work was supported by NIH U19 AI110483 to J.M.B. and I.S., P01 AI125180 to I.S., E.H.L., and J.M.B., RO1 AI113021 to J.M.B., F31 AI112261 to B.G.B., and T32 GM008490 to J.M.B.
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.