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Author Notes:

Laura A. Schieve, Phone: 498-3888, Email: lschieve@cdc.gov

Subject:

Research Funding:

This research is partially supported by the NIH Director’s Pioneer Award program, part of the NIH Roadmap for Medical Research, through Grant Number 1 DP1 OD003635-01 and the National Institutes of Mental Health Award Number R21MH096122.

Keywords:

  • Social Sciences
  • Psychology, Developmental
  • Psychology
  • Infantile autism
  • Symptom severity
  • Diagnosis age
  • Assisted reproductive technology
  • 2007 NATIONAL-SURVEY
  • SPECTRUM DISORDERS
  • POPULATION
  • BORN
  • CONCEPTION
  • PREVALENCE
  • OUTCOMES
  • ASSOCIATION
  • CALIFORNIA
  • SINGLETON

Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?

Tools:

Journal Title:

Journal of Autism and Developmental Disorders

Volume:

Volume 45, Number 9

Publisher:

, Pages 2991-3003

Type of Work:

Article | Final Publisher PDF

Abstract:

Previous studies report associations between conception with assisted reproductive technology (ART) and autism. Whether these associations reflect an ascertainment or biologic effect is undetermined. We assessed diagnosis age and initial autism symptom severity among >30,000 children with autism from a linkage study of California Department of Developmental Services records, birth records, and the National ART Surveillance System. Median diagnosis age and symptom severity levels were significantly lower for ART-conceived than non-ART-conceived children. After adjustment for differences in the socio-demographic profiles of the two groups, the diagnosis age differentials were greatly attenuated and there were no differences in autism symptomatology. Thus, ascertainment issues related to SES, not ART per se, are likely the driving influence of the differences we initially observed.

Copyright information:

© 2015, The Author(s).

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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