211 Views | 72 Downloads
To whom correspondence may be addressed. Emails: rino.r.rappuoli@gsk.com; bpulend@emory.edu; claire-anne.siegrist@unige.ch
Author contributions: G.D.G., R.R., V.C., A.J.P., B.P., and C.-A.S. designed research; H.I.N., E.C., D.K., L.W., M.C., S.E.B., N.B.P., D.E.Z., and T.D. performed research; A.A., G.D.G., R.R., V.C., A.J.P., B.P., and C.-A.S. analyzed data; and H.I.N., E.C., D.K., R.R., A.J.P., B.P., and C.-A.S. wrote the paper.
Reviewers: A.G.-S., Icahn School of Medicine at Mount Sinai; S.H.E.K., Max Planck Institute for Infection Biology; and F.S., Institute for Research in Biomedicine, Università della Svizzera Italiana.
H.I.N., E.C., D.K., and L.W. contributed equally to this work.
We thank Dr. Angus Goodson, Elizabeth Davies, Hannah Robinson, and Richard Sewell for assisting with the clinical trial; Amber Thompson, Jaclyn Bowman, Susan Ndimah, Karlijn De Nie, and Rebecca Sie for assisting with laboratory evaluation; and the families who participated in this study.
Conflict of interest statement: R.R. and G.D.G. are full-time employees at Glaxo-Smith-Kline Vaccines. C.-A.S. is a member of several advisory committees on vaccination and has received research grants from vaccine manufacturers for preclinical and clinical research, all unrelated to this work. A.J.P. chairs the United Kingdom Department of Health’s Joint Committee on Vaccination and Immunization and the European Medicines Agency scientific advisory group on vaccines. He has previously conducted clinical trials in behalf of Oxford University funded by vaccine manufacturers, including manufacturers of influenza vaccines, but no longer does so.
This study was supported in part by European Commission FP7 Grant “Advanced Immunisation Technologies”; the National Institute for Health Research Oxford Biomedical Research Centre; and the Medical Research Council (to the Human Immunology Unit). Work in B.P.’s laboratory was supported by National Institutes of Health Grants U19AI090023, R37AI48638, R37DK057665, U19AI057266, and AI100663-02. H.I.N. is the recipient of a CNPq research fellowship.
Nakaya et al