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Author Notes:

Corresponding author at: Ofer Sadan, Department of Neurology, Tel-Aviv Sourasky Medical Center, 6 Weizmann St., Tel-Aviv, Israel. ofer.sadan@gmail.com

Contributed equally to this manuscript: OS and ES.

Esther Eshkol is thanked for editorial assistance.



  • AED
  • Hashimoto's encephalopathy
  • Hypersensitivity
  • Temporal lobe epilepsy

Adult-onset temporal lobe epilepsy, cognitive decline, multi-antiepileptic drug hypersensitivity, and Hashimoto's encephalopathy: Two case studies


Journal Title:

Epilepsy and Behavior Case Reports


Volume 1, Number 1


, Pages 132-135

Type of Work:

Article | Final Publisher PDF


Hashimoto's encephalopathy is defined by the coexistence of encephalopathy and antithyroid antibodies. We report two cases of adult-onset temporal lobe epilepsy with subacute cognitive decline, high titers of antithyroid antibodies, multi-antiepileptic drug hypersensitivity, and good response to immunomodulatory treatment. The relevance of multidrug hypersensitivity in the setting of adult-onset epilepsy and the importance of searching for autoimmune causes for epilepsy are discussed.

Copyright information:

© 2013 The Authors.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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