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Author Notes:

Peng Yin: py@hms.harvard.edu

Yonggang Ke: yonggang.ke@emory.edu

Y.K., L.L.O. and W.S. made equal contributions.

Y.K. conceived the project, designed and performed the experiments, analyzed the data, and wrote the paper; L.L.O. and W.S. designed and performed the experiments, analyzed the data, and wrote the paper; J.S. and M.D. performed the cryo-EM and AFM experiments, analyzed the data, and wrote the paper; W.M.S discussed the results and wrote the paper; P.Y. conceived, designed, and supervised the study, interpreted the data, and wrote the paper.

The authors declare competing financial interests: a provisional US patent application has been filed.

Subjects:

Research Funding:

This work is supported by an ONR Young Investigator Program Award N000141110914; ONR Grants N000141010827, N000141410610, N000141310593; an ARO Grant W911NF1210238; an NSF CAREER Award CCF1054898; an NSF Expedition in Computing Award CCF1317291; NSF Grants CCF1162459, CMMI1333215, CMMI1334109, CMMI1344915; an NIH Director’s New Innovator Award 1DP2OD007292; and a Wyss Institute Faculty Startup Fund to P.Y.; and by a Wyss Institute Faculty Grant; ARO MURI grant W911NF1210420; ONR Grants N000014091118 and N000141010241; and an NIH Director’s New Innovator Award 1DP2OD004641 to W.M.S.

L.L.O. is supported by a NSF Graduate Research Fellowship.

J.S. acknowledges AUFF founding from Aarhus University and Niels Bohr Foundation from The Royal Danish Academy of Science.

M.D. acknowledges financial support from the Danish National Research Foundation, and the Villum Foundation.

Keywords:

  • Science & Technology
  • Physical Sciences
  • Chemistry, Multidisciplinary
  • Chemistry
  • SINGLE-STRANDED-DNA
  • NANOSCALE SHAPES
  • GOLD NANOPARTICLES
  • BLOCK-COPOLYMERS
  • FOLDING DNA
  • ARRAYS
  • NANOSTRUCTURES
  • JUNCTIONS
  • DESIGN
  • ORIGAMI

DNA brick crystals with prescribed depths

Journal Title:

Nature Chemistry

Volume:

Volume 6, Number 11

Publisher:

, Pages 994-1002

Type of Work:

Article | Post-print: After Peer Review

Abstract:

The ability to assemble functional materials with precise spatial arrangements is important for applications ranging from protein crystallography to photovoltaics. Here, we describe a general framework for constructing two-dimensional crystals with prescribed depths and sophisticated three-dimensional features. The crystals are self-assembled from single-stranded DNA components called DNA bricks. We demonstrate the experimental construction of DNA brick crystals that can grow to micrometre size in their lateral dimensions with precisely controlled depths up to 80 nm. They can be designed to pack DNA helices at angles parallel or perpendicular to the plane of the crystal and to display user-specified sophisticated three-dimensional nanoscale features, such as continuous or discontinuous cavities and channels.

Copyright information:

Copyright © 2014, Springer Nature

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