About this item:

56 Views | 23 Downloads

Author Notes:

E-mail address: shonna.mcbride@emory.edu.

We give special thanks to Charles Moran, Kathryn Nawrocki and members of the McBride lab for helpful criticism of this manuscript.

Subject:

Research Funding:

This work was supported by the U.S. National Institutes of Health through research grants DK087763 and DK101870 to S.M.M.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Microbiology
  • spores
  • endospore
  • anaerobe
  • sporulation
  • nutrition
  • phosphorylation
  • TRANSCRIPTION FACTOR SPO0A
  • TOXIN GENE-EXPRESSION
  • BACILLUS-SUBTILIS
  • HISTIDINE KINASES
  • PROTEIN-KINASE
  • CHROMOSOME SEGREGATION
  • CATABOLITE REPRESSION
  • REGULATORY PROTEINS
  • ENDOSPORE FORMATION
  • STATIONARY-PHASE

Initiation of sporulation in Clostridium difficile: a twist on the classic model

Tools:

Journal Title:

FEMS Microbiology Letters

Volume:

Volume 358, Number 2

Publisher:

, Pages 110-118

Type of Work:

Article | Post-print: After Peer Review

Abstract:

The formation of dormant endospores is a complex morphological process that permits long-term survival in inhospitable environments for many Gram-positive bacteria. Sporulation for the anaerobic gastrointestinal pathogen Clostridium difficile is necessary for survival outside of the gastrointestinal tract of its host. While the developmental stages of spore formation are largely conserved among endospore-forming bacteria, the genus Clostridium appears to be missing a number of conserved regulators required for efficient sporulation in other spore-forming bacteria. Several recent studies have discovered novel mechanisms and distinct regulatory pathways that control the initiation of sporulation and early-sporulation-specific gene expression. These differences in regulating the decision to undergo sporulation reflects the unique ecological niche and environmental conditions that C. difficile inhabits and encounters within the mammalian host.

Copyright information:

© 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

Export to EndNote