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Author Notes:
Corresponding Author: Canhua Xiao, PhD RN, Assistant Professor, Nell Hodgson Woodruff School of Nursing, Emory University, 1520 Clifton Road, Room 234, Atlanta, GA 30322, Tel: 404 712 9823, Fax: 404 727 8514, cxiao2@emory.edu
The authors appreciate the support from Emory University School of Nursing, School of Medicine, and Winship Cancer Institute.
The authors declare no potential conflicts of interest.
Subjects:
Research Funding:
The study was supported by NIH/NINR K99/R00NR014587, NIH/NINR R01NR015783, NIH/NCI P30CA138292 and Oncology Nursing Society Foundation.
Keywords:
- Science & Technology
- Life Sciences & Biomedicine
- Immunology
- Neurosciences
- Psychiatry
- Neurosciences & Neurology
- QUALITY-OF-LIFE
- HUMAN-PAPILLOMAVIRUS
- RADIOTHERAPY
- INFLAMMATION
- EXPRESSION
- SURVIVAL
- IMMUNITY
Differential regulation of NF-kB and IRF target genes as they relate to fatigue in patients with head and neck cancer
Abstract:
Previous studies have linked plasma inflammatory markers to elevated fatigue in patients with head and neck cancer (HNC). To identify the molecular mechanisms underlying this association, we conducted promoter-based bioinformatics analyses to determine the relationship between fatigue and specific gene expression profiles associated with inflammation in human papillomavirus (HPV)-related and -unrelated HNC patients undergoing treatment. Patients with newly diagnosed HNC without distant metastasis were assessed at baseline (pre-radiotherapy) and one-month post-radiotherapy. Fatigue was measured by the Multidimensional Fatigue Inventory. Genome-wide gene expression profiles were collected from peripheral blood mononuclear cells (PBMC). Promoter-based bioinformatics analyses were employed to identify transcription control pathways underlying transcriptomic correlates of fatigue in the sample as a whole and in HPV-related and HPV-unrelated HNC patients separately. In transcriptome profiling analyses of PBMC from 44 patients, TELiS bioinformatics analyses linked fatigue to increased nuclear factor-kappa B (NF-kB) transcriptional activity and decreased interferon regulatory factor family (IRF) transcription factor activity. Patients with HPV-related HNC showed lower levels of fatigue-related gene expression profile compared to HPV-unrelated HNC. Fatigue in HNC patients undergoing treatment is associated with gene expression profiles consistent with the conserved transcriptional response to adversity (CTRA) characterized by increased proinflammatory and decreased anti-antiviral transcriptional activity. Interestingly, this CTRA response was mitigated in patients with HPV-related HNC and may explain the lower level of fatigue they experience relative to HPV-unrelated HNC.
Copyright information:
© 2018 Elsevier Inc.
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
