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Author Notes:

Corresponding author: Mona Saraiya, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, MS F-76, Atlanta, GA 30341, phone: 770-488-4708, fax: 770-488-4760, cgelb@cdc.gov


Research Funding:

This study was funded through CDC’s Inside Knowledge: Get the Facts about Gynecologic Cancer campaign.


  • HPV testing
  • Pap test
  • cervical cancer
  • screening
  • women's health
  • acceptance

Primary HPV testing: U.S. women's awareness and acceptance of an emerging screening modality


Journal Title:

Preventive Medicine


Volume 108


, Pages 111-114

Type of Work:

Article | Post-print: After Peer Review


Background Primary HPV testing (without the Pap test) has recently been recommended as a cervical cancer screening option in the United States. U.S. women’s awareness and acceptance of primary HPV testing were evaluated. Methods Data from a 2015 web-based survey of U.S. adults was examined. Analyses were limited to women who were ≥18 years old, had not undergone a hysterectomy, had not been diagnosed with cervical cancer, and would accept cervical cancer screening (N=1,309). Logistic regression was used to identify predictors of acceptance of primary HPV testing every 3 years. Results Primary HPV testing every 3 years was the least accepted cervical cancer screening option (13.5%), and annual Pap testing was the most accepted (41.2%). Most women (65.2%) reported that they were unsure how the HPV test is administered. HPV-vaccinated women were more likely to accept primary HPV testing every 3 years than unvaccinated women (Adj OR=1.80, 95% CI=1.22-2.63, p=0.003). And, women who had participated in HPV testing at any interval were more likely to accept primary HPV testing every 3 years than those who did not have regular HPV tests or were unsure how often they had HPV tests (Adj OR=1.74, 95% CI=1.20-2.52, p=0.003). Conclusions Acceptance of primary HPV testing among U.S. women was low and associated with variables which may be indicative of general HPV awareness. Widespread adoption of primary HPV testing may require increasing women’s familiarity with the HPV test and screening guidelines.

Copyright information:

Published by Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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