The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions

• Authors: Michael Woodworth, Emory University; Mary K Hayden, Rush Medical College; Vincent B. Young, University of Michigan; Jennie H. Kwon, Washington University St. Louis
• Journal Title: Open Forum Infectious Diseases
• Volume: Volume 6, Number 7
• Publisher: Oxford University Press (OUP) | 2019-07-01
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1093/ofid/ofz288
• Subjects: Health Sciences, Immunology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Immunology; Infectious Diseases; Microbiology; antibiotic resistance; antibiotic-resistant organism; fecal microbiota transplantation; hospital epidemiology; microbiome; multidrug-resistant organisms; resistome; CLOSTRIDIUM-DIFFICILE INFECTION; KLEBSIELLA-PNEUMONIAE; SUCCESSFUL RESOLUTION; DONOR FECES; VANCOMYCIN; RECURRENT; ENTEROBACTERIACEAE; ERADICATION; TRACT; ENTEROCOCCI

Abstract

The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and a potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established as an effective treatment for recurrent Clostridioides difficile infection and may be an effective approach for reducing intestinal ARO colonization. In this article, we review the current published literature on the role of FMT for eradication of intestinal ARO colonization, review the potential benefit and limitations of the use of FMT in this setting, and outline a research agenda for the future study of FMT for intestinal ARO colonization.