Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

• Authors: Maureen Wirschell, Emory University; Ryosuke Yamamoto, Emory University; Lea Alford, Emory University; Avanti S Gokhale, Emory University; Anne Gaillard, Sam Houston State University; Winfield S. Sale, Emory University
• Journal Title: Archives of Biochemistry and Biophysics
• Volume: Volume 510, Number 2
• Publisher: Elsevier: 12 months | 2011-06-15, Pages 93-100
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1016/j.abb.2011.04.003
• Subjects: Biology, Cell

Abstract

Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation / dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.