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Author Notes:
Correspondence: Victor G. Corces; Email: vcorces@emory.edu and Jennifer E. Phillips; Email: jephill@emory.edu
Acknowledgments: The authors thank T. Misteli and J. M. Boss for valuable insights and critical review of the manuscript.
We also acknowledge B. van Steensel and J. T. Lee, as well as past and present members of the Corces lab, in particular A. Bushey and E. Doorman, for helpful discussions.
Subjects:
Research Funding:
V.G.C. is funded by a U.S. Public Health Service Award (GM35463) from the NIH and J.E.P. is supported by an NIH NRSA postdoctoral fellowship.
CTCF: Master Weaver of the Genome
Abstract:
CTCF is a highly conserved zinc finger protein implicated in diverse genomic regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X-chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF-mediated intra- and inter-chromosomal contacts at several developmentally regulated genomic loci. These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.
Copyright information:
© 2009, Elsevier
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).
