About this item:

724 Views | 202 Downloads

Author Notes:

Correspondence: Robert C. Castellino, Email: rccaste@emory.edu


Research Funding:

This work was supported by grants from St. Baldrick’s Foundation (R.C.C.), CURE Childhood Cancer Foundation (R.C.C.), Southeastern Brain Tumor Foundation (R.C.C.), and the Emory Egleston Children’s Research Center (R.C.C.)


  • Medulloblastoma
  • Relapse
  • Bevacizumab
  • Irinotecan
  • Temozolomide

Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience


Journal Title:

Child's Nervous System


Volume 29, Number 4


, Pages 589-596

Type of Work:

Article | Post-print: After Peer Review


Purpose Chemotherapy for relapsed medulloblastoma has been inadequate, and most patients succumb to disease. Methods We retrospectively reviewed nine cases of relapsed medulloblastoma treated with bevacizumab, irinotecan, ±temozolomide. Patients received one to three prior therapeutic regimens. Five patients received 10 mg/kg bevacizumab and 125–150 mg/m2 irinotecan IV every 2 weeks, with temozolomide, starting at a median dose of 150 mg/m2 orally for 5 days monthly. Two patients received bevacizumab and irinotecan, but not temozolomide, due to provider preference. Two of nine patients received 15 mg/kg bevacizumab IV, 90 mg/m2 irinotecan orally for five consecutive days, 100 mg/m2/day temozolomide IV for 5 days, and 1.5 mg/m2 vincristine IV, each administered every 21 days. Results Median time to progression was 11 months. Median overall survival was 13 months. Objective tumor response at 3 months was 67 %, including six patients with partial response (PR) and three patients with stable disease (SD). At 6 months, objective response was 55 %, with two patients with PR and three with complete response. Additionally, one patient had SD and three had PD. Two patients remain alive and progression free at 15 and 55 months; another is alive with disease at 20 months. Toxicities included two patients with grade III neutropenia, two with grade III thrombocytopenia, one with grade III elevation of liver function tests, and one patient with grade III diarrhea. Conclusions The combination of bevacizumab and irinotecan, with or without temozolomide, produces objective responses with minimal toxicity in children with recurrent medulloblastoma. Prospective clinical trials are needed to evaluate the efficacy of this strategy.

Copyright information:

© Springer-Verlag Berlin Heidelberg 2013

Export to EndNote