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Author Notes:

Correspondence: Peng Jin, Ph.D. Department of Human Genetics Emory University School of Medicine 615 Michael Street, Suite 301 Atlanta, Georgia 30322; Tel: (404) 727-3729; Fax: (404) 727-5408; Email: peng.jin@emory.edu

Acknowledgments: The authors would like to thank C. Strauss for critical reading of the manuscript.

Subjects:

Research Funding:

H.T. is supported by the China Scholarship Council. P.J. is supported by NIH grants (R01 NS051630 and R21 NS067461).

Role of noncoding RNAs in Trinucleotide repeat neurodegenerative disorders

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Journal Title:

Experimental Neurology

Volume:

Volume 235, Number 2

Publisher:

, Pages 469-475

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Increasingly complex networks of noncoding RNAs are being found to play important and diverse roles in the regulation of gene expression throughout the genome. Many lines of evidence are linking mutations and dysregulations of noncoding RNAs to a host of human diseases, and noncoding RNAs have been implicated in the molecular pathogenesis of some neurodegenerative disorders. The expansion of trinucleotide repeats is now recognized as a major cause of neurological disorders. Here we will review our current knowledge of the proposed mechanisms behind the involvement of noncoding RNAs in the molecular pathogenesis of neurodegenerative disorders, particularly the sequestration of specific RNA-binding proteins, the regulation of antisense transcripts, and the role of the microRNA pathway in the context of known neurodegenerative disorders caused by the expansion of trinucleotide repeats.

Copyright information:

© 2012 Elsevier Inc. All rights reserved

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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