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Author Notes:

Corresponding author: Monika L. Metzger, MD, MSc, 262 Danny Thomas Pl, Memphis, TN 38105; e-mail: monika.metzger@stjude.org

Conception and design: Monika L. Metzger, Lillian R. Meacham, Jacqueline S. Casillas, Nobuko Hijiya, Lisa B. Kenney, Marcia Leonard, Barbara A. Lockart, Wendy Likes, Daniel M. Green

Collection and assembly of data: Monika L. Metzger, Briana Patterson, Jacqueline S. Casillas, Wendy Likes

Data analysis and interpretation: Monika L. Metzger, Briana Patterson, Jacqueline S. Casillas, Louis S. Constine, Nobuko Hijiya, Barbara A. Lockart, Wendy Likes

Manuscript writing: All authors

Final approval of manuscript: All authors

The author(s) indicated no potential conflicts of interest.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • ANTI-MULLERIAN HORMONE
  • CENTRAL PRECOCIOUS PUBERTY
  • TERM-FOLLOW-UP
  • ACUTE LYMPHOBLASTIC-LEUKEMIA
  • CRYOPRESERVED OVARIAN TISSUE
  • VERSUS-HOST-DISEASE
  • FERTILITY PRESERVATION
  • HODGKINS-DISEASE
  • BREAST-CANCER
  • REPLACEMENT THERAPY

Female Reproductive Health After Childhood, Adolescent, and Young Adult Cancers: Guidelines for the Assessment and Management of Female Reproductive Complications

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Journal Title:

Journal of Clinical Oncology

Volume:

Volume 31, Number 9

Publisher:

, Pages 1239-1247

Type of Work:

Article | Final Publisher PDF

Abstract:

Purpose: As more young female patients with cancer survive their primary disease, concerns about reproductive health related to primary therapy gain relevance. Cancer therapy can often affect reproductive organs, leading to impaired pubertal development, hormonal regulation, fertility, and sexual function, affecting quality of life. Methods: The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer (COG-LTFU Guidelines) are evidence-based recommendations for screening and management of late effects of therapeutic exposures. The guidelines are updated every 2 years by a multidisciplinary panel based on current literature review and expert consensus. Results: This review summarizes the current task force recommendations for the assessment and management of female reproductive complications after treatment for childhood, adolescent, and young adult cancers. Experimental pretreatment as well as post-treatment fertility preservation strategies, including barriers and ethical considerations, which are not included in the COG-LTFU Guidelines, are also discussed. Conclusion: Ongoing research will continue to inform COG-LTFU Guideline recommendations for follow-up care of female survivors of childhood cancer to improve their health and quality of life.

Copyright information:

© 2013 by American Society of Clinical Oncology.

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