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Author Notes:

Correspondence: Michael Goodman MD, MPH, Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Road, NE, Atlanta GA 30322; Email: mgoodm2@sph.emory.edu

Subjects:

Research Funding:

The funding for this publication was provided by the National Cancer Institute (grant R01 CA116795-01) and by the Woodruff Health Sciences Fund

Keywords:

  • prostate cancer
  • colorectal adenoma
  • oxidative balance score

Combined measure of pro- and anti-oxidant exposures in relation to prostate cancer and colorectal adenoma risk: an update

Tools:

Journal Title:

Annals of Epidemiology

Volume:

Volume 20, Number 12

Publisher:

, Pages 955-957

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Purpose We previously proposed an oxidative balance score (OBS) and illustrated its practical application by using data from previously completed case-control studies of two neoplasms – sporadic colorectal adenoma and prostate cancer. In the present study we extend our analysis by substituting questionnaire-based measures with systemic biomarkers of pro- and anti-oxidant exposures. Methods Low, medium and high pro-oxidant exposures, and high, medium and low antioxidant exposures were assigned 0, 1 and 2 points, respectively and individual points for all exposures were then summed to calculate the overall score. Case and controls were compared using logistic regression analysis after adjusting for covariates. Results When OBS was treated as a continuous variable the adjusted odds ratios and 95% confidence intervals (CI) for each additional score point were the same: 0.90 (95% CI: 0.83–0.97) for each study. When the OBS was divided into three approximately equal intervals, a comparison of the lowest to highest category showed similar adjusted ORs (95% CIs) of 0.34 (0.13–0.88) and 0.34 (0.14–0.86) for colorectal adenoma and prostate cancer, respectively. Conclusions Our analyses provide support for the stated hypothesis that combined measures of pro- and anti-oxidant exposures may be associated with oxidative stress-related conditions.

Copyright information:

© 2010 Elsevier Inc. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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