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Author Notes:

Sarah Kidd, MD, MPH, 1600 Clifton Rd NE, MS E-63, Atlanta, GA 30329-4027 (hgk9@cdc.gov).

We thank Hunter Handsfield, Ned Hook, Bob Kirkcaldy, Fred Sparling, and Jonathan Zenilman for providing their input on the key questions and their assistance in the development of the treatment guidelines.

Authors reported no conflicts of interest.

Subjects:

Research Funding:

This article appears as part of the supplement “Evidence Papers for the CDC Sexually Transmitted Diseases Treatment Guidelines,” sponsored by the Centers for Disease Control and Prevention.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • Microbiology
  • gonorrhea
  • Neisseria gonorrhoeae
  • drug therapy
  • RESISTANT NEISSERIA-GONORRHOEAE
  • ACID AMPLIFICATION TESTS
  • SEXUALLY-TRANSMITTED INFECTIONS
  • SINGLE-DOSE AZITHROMYCIN
  • HIGH-LEVEL RESISTANCE
  • IN-VITRO ACTIVITY
  • PHARYNGEAL GONORRHEA
  • TREATMENT FAILURE
  • UNCOMPLICATED GONORRHEA
  • GONOCOCCAL INFECTIONS

Management of Gonorrhea in Adolescents and Adults in the United States

Tools:

Journal Title:

Clinical Infectious Diseases

Volume:

Volume 61, Number suppl 8

Publisher:

, Pages S785-S801

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Gonorrhea is the second most commonly reported notifiable disease in the United States and is associated with serious health sequelae, including pelvic inflammatory disease, infertility, and ectopic pregnancy. Treatment for gonorrhea has been complicated by antimicrobial resistance. Neisseria gonorrhoeae has developed resistance to each of the antimicrobials that were previously recommended as first-line treatment regimens, and current treatment options are severely limited. This article summarizes the key questions and data that were discussed at the Sexually Transmitted Diseases (STD) Treatment Guidelines Expert Consultation meeting in April 2013, and the rationale for the 2015 Centers for Disease Control and Prevention STD treatment guidelines for gonococcal infections in adolescents and adults. Key issues addressed include whether to change the dosage of ceftriaxone and azithromycin used in the recommended dual treatment regimen, whether to continue to list dual treatment with cefixime and azithromycin as an alternative treatment regimen, and management of gonococcal infections in persons with severe cephalosporin allergy or suspected treatment failure.

Copyright information:

© 2015 Published by Oxford University Press for the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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