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Author Notes:

Correspondence: Vasiliki Michopoulos, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329; Phone: 1-404-712-9420; Fax: 1-404-727-8088; Email: vmichop@emory.edu

Acknowledgments: The study was conducted with the expert technical assistance of Jennifer Whitley, Shannon Bounar, Jodi Godfrey, Christine Marsteller, Jonathon Lowe, Rebecca Herman, Robert Johnston and Gregory Henry.

This study would not have been possible without the dedication of the animal husbandry staff at the YNPRC.

Disclosures: All authors declare that they have no conflicts of interest.

The YNPRC is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care, International.

Subjects:

Research Funding:

Funding support for this study was provided by NIH grants HD46501 (MW), MH081816 (DT), RR00165, and F31MH085445 (VM).

Further support was provided by the Center for Behavioral Neuroscience through the STC Program of the National Science Foundation IBN-9876754.

Keywords:

  • Psychosocial stress
  • Social subordination
  • Diet choice
  • Monkeys
  • Emotional feeding

Social stress interacts with diet history to promote emotional feeding in females

Tools:

Journal Title:

Psychoneuroendocrinology

Volume:

Volume 37, Number 9

Publisher:

, Pages 1479-1490

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Stress-induced eating disorders cause significant health problems and are often comorbid with mood disorders. Emotional feeding, particularly in women, may be important for the development of obesity and failed attempts to lose weight. However, prospective studies assessing the effect of chronic psychosocial stress on appetite in different dietary environments in females are lacking. The present study tested the hypothesis that chronic psychosocial stress would increase consumption of high caloric diet and this emotional feeding would persist even when a healthier diet was available. Socially housed female rhesus monkeys were studied to address whether subordination increases caloric intake when a high fat and sugar diet (HFSD) was available concurrently with a low fat, high fiber diet (LCD). Cortisol responsivity and food intake were quantified during this choice phase and when only the LCD was available. The order of diet condition was counterbalanced to assess whether a history of HFSD would affect appetite. All females preferred the HFSD but subordinates consumed significantly more calories during the choice phase. The increased calorie intake was maintained in subordinate monkeys even after withdrawal of the HFSD. Subordinate females demonstrated reduced glucocorticoid negative feedback, with post dexamethasone serum cortisol levels significantly predicting intake of the HFSD but not the LCD during the choice condition. The cortisol response to an acute stressor significantly predicted subsequent intake of a HFSD in all females. Continual exposure to the psychosocial stress of subordination in female monkeys results in excess caloric intake of foods that mimic a western dietary environment. In addition, this social stressor interacts with a history of HFSD intake to promote increased feeding even in a healthy dietary environment.

Copyright information:

© 2012 Elsevier Ltd. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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