Inducible nitric oxide synthase is crucial for plasma cell survival

• Authors: Modesta N Njau, Emory University; Joshy Jacob, Emory University
• Journal Title: Nature Immunology
• Volume: Volume 15, Number 3
• Publisher: Nature Research (part of Springer Nature) | 2014-03-01, Pages 219-221
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1038/ni.2831
• Subjects: Health Sciences, Immunology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Immunology; APOPTOSIS

Abstract

The viability of long-lived plasma cells is enhanced by the expression of inducible nitric oxide synthase, which relieves endoplasmic reticulum stress by triggering a response dependent on cGMP and protein kinase G.